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PI3K-AKT通路专题解析（上） - 知乎

PI3K-AKT通路专题解析（上） - 知乎切换模式写文章登录/注册PI3K-AKT通路专题解析（上）基迪奥生物专业定制测序服务。我们的愿望是，助您达到更高的科研领域。在上期文章中，周老师向大家介绍了Kegg通路背后的网络关系以及核心通路（文章链接：《Kegg通路背后的网络关系以及核心通路》），本周开始我们将陆续解析35个核心通路，首先就来看看PI3K-AKT信号通路吧！PI3K-AKT信号通路简介及在kegg通路中的位置PI3K-AKT途径是一种细胞内信号转导途径，响应细胞外信号，促进代谢、增殖、细胞存活、生长和血管生成。这一过程是通过一系列下游底物的丝氨酸或苏氨酸磷酸化介导的，涉及的关键基因是磷脂酰肌醇3-激酶(PI3K)和AKT/蛋白激酶b，所以这一通路直接用这两个基因命名。图1 PI3K-AKT通路示意图[1]如同前文提到的，PI3K-AKT在我们的核心35通路中有着连接两类通路簇的作用。在这个35个通路中，PI3k-AKT通路一共与14个通路存在直接连接。图2-1 35个核心通路中与PI3K-AKT直接相关相关的通路图2-2 PI3K-AKT最直接相关的71个网络示意图如果放眼整个kegg数据库，与PI3K-AKT通路存在直接关系的通路类型高达71个，可见其重要性（图2-2）。当然网路图可能看不清楚，主要是成员太多了。如果对71个通路按照A级别进行分类，可以看到最大的一类是Human Diseases，可见PI3K-AKT与大量人类疾病相关。其次是Environmental Information processing，一共涉及18个通路，全部都是信号传导相关的（表1），其中包括MAPK signaling pathway，Ras signaling pathway，AMPK signaling pathway等在文章里我们反复见到的通路。可见，这些通路都是一环套一环的，如果不能从全局了解他们的关系，我们难免进入盲人摸象般的迷茫。图3 与PI3K-AKT相关的71个通路的分类PI3K-AKT通路简要结构单纯看一眼kegg通路网络，我们往往会被吓一跳。但如果我们对网路图进行拆解，就会容易很多。PI3K-AKT网路图可以分为三大部分，分别为：（1）PI3K-AKT上游（图4蓝框）主要响应细胞外信号（图中双竖线为细胞膜），以激活PI3K-AKT核心过程。从这个部分，你可以看到Toll like receptor，B cell receptor，JAK/STAT等一溜信号传导途径，通通都是可以将信号传递给PI3K-AKT的。（2）PI3K-AKT核心（图4红框）涉及两个核心蛋白的激活以及信号传递，后续专门介绍。（3）PI3K-AKT下游（图4绿框）PI3K-AKT信号激活后，会传递给下游通路，导致一系列通路被激活，包括蛋白翻译，细胞周期，细胞凋亡，P53通路等。图4 PI3K-AKT网络图拆分PI3K-AKT通路的核心步骤上文提到过，PI3K、AKT这两个分子是这个通路最关键的两个分子，所以它们互作的过程就是这一通路的核心步骤。如下图左图是kegg通路图中PI3K和AKT互作的部分，kegg图形虽然简洁，但比较抽象，如果没有解释很难看懂。但看下图右图就会直观很多。PI3K-AKT两个分子互作关系主要还涉及其他2个代谢物和2个编码基因，关键代谢物为PIP2（磷脂酰肌醇-4，5-二磷酸）和PIP3（磷脂酰肌醇-3，4，5-二磷酸），关键基因PTEN（脂质磷酸酶）和PDK1（3-磷酸肌醇依赖性蛋白激酶-1）。图5 从两类不同图形观察PIP3和AKT之间的信号传递PI3K和AKT的互作，可以看成两个步骤：（1）PIP2与PIP3的相互转化涉及PI3K和PTEN的调控。PI3K可以将代谢物PIP2磷酸化为PIP3(加一个3位磷酸基团)。而脂质磷酸酶（例如PTEN），则可以代谢（去磷酸化）PIP3，使之变回PIP2，从而终止PI3K信号通路（备注：图5右图PTEN的标注有歧义，PTEN的作用是促进去磷酸化PIP3从而抑制其在细胞内累积）。在这个过程里，如果PI3K比喻成信号传递的油门的话，PTEN就是刹车。图6 PI3K可以磷酸化PIP2为PIP3，PTEN则可以逆转这个过程（2）PIP3促进AKT的活化PIP2和PIP3是细胞膜的次要磷脂成分。PI3K的下游效应主要体现在对PIP3的调控作用。PIP3充当第二信使，可以促进具有PH结构域的蛋白向质膜的募集和随后信号级联的激活。在PI3K-AKT途径中，PIP3的3位磷酸基团可同时招募PDK1和AKT蛋白到质膜上，使PDK1磷酸化AKT蛋白的308号位的苏氨酸（T308），导致AKT部分活化。被活化的AKT将进一步激活下游调控通路。下文，我们将重点了解PI3K和AKT两个基因，以及与它们相关的PI3K-AKT通路的上游以及下游过程。PI3K激酶二聚物介绍磷脂酰肌醇3-激酶（Phosphatidylinositide 3-kinases，PI3K）是一种胞内磷脂酰肌醇激酶。但该酶不是单个基因，而是一种二聚物体复合物，由催化亚基（catalytic subunit）和调节亚基（regulatory subunit）构成。即，这个激酶复合物由两个基因构成，且每个亚基成分可以来源不同的同源基因。你可以试试将鼠标移动到PI3K-AKT的KEGG map的PI3K基因上（如下图），在弹出的窗口中可以看到这个分子对应的基因两个K号，每个K号对应三个基因。其中，K00922是催化亚基，对应PI3KCA/B/D三个基因（即可能来源这3个基因中的一个）；K02649是调节亚基，对应PIK3R1/2/3三个基因（可能来源这3个基因中的一个）。所以，下次你看转录组数据里，KEGG通路每个节点红红绿绿的颜色（红色通常代表上调，绿色代表下调），一定还要点击打开看看具体是这个位点的哪些基因发生了变化。比如，在PI3K这个位置，催化亚基发生变化和调节亚基发生变化，当然代表不同的生物学意义。图7 在KEGG map中鼠标移动到PI3K（Class IA）对应的信息在KEGG map中，你可能会注意到PI3K的图标还下面写着Class IA和Class IB。这其实是针对PI3K催化亚基来命名的。人类细胞表达三类PI3K催化亚基，PI3K-AKT通路中特指的是I类催化亚基；哺乳动物表达四种I类催化亚基(p110α、β、δ和γ)，由以下基因编码PIK3CA、PIK3CB、PIK3CD和PIK3CG，它们都可以将PIP2磷酸化为PIP3。在正常细胞中PIP3由生长因子刺激瞬时诱导，并被脂质磷酸酶（例如，PTEN）快速代谢去磷酸化从而终止PI3K信号。癌细胞经常含有大量的PIP3，这是由于位于PI3K上游的致癌信号蛋白的活性增加或PI3K本身的突变激活（相当于油门的功率太强了）。许多癌症还表现出PTEN功能的丧失，从而丧失了PIP3的代谢能力（相当于刹车失灵）。在癌症基因组测序研究的荟萃分析中，PIK3CA和PTEN被发现是人类癌症中第二和第三大高度突变基因（油门和刹车失灵都会导致汽车失控啊）。p110α和p110β蛋白普遍表达，而p110γ和p110δ的表达在免疫细胞中富集。其中P110α、β、δ（PIK3CA、PIK3CB、PIK3CD）属于Class IA，p110γ（PIK3CG）属于Class IB，对应的结构域略有不同（如下图）。Class IA和Class IB对应不同的调节亚基（Regulatory）配对。调节亚基的作用是调节复合物的活性和亚细胞定位。比如，Class IA的调节亚基含有SH2结构域，其可以与生长因子受体或衔接蛋白如IRS1上的磷酸酪氨酰残基结合，介导复合物的催化亚基p110与细胞质膜的结合（定位），从而可以行使其磷酸化PIP2的功能。图8 PI3K I类亚族的催化亚基与调节亚基的蛋白结构域构成，这里PXXX的意思是蛋白分子量。例如，P110意思是这个亚基的分子量为110 kDa（千道尔顿）图中结构域全称：ABD：adaptor-binding domain；接头绑定结构域；RBD：Ras-binding domain；Ras结合域；BH：breakpoint cluster region homology；断点簇区域同源性；Helical kinase：螺旋激酶；C2：C2催化亚基结构域；N-SH2：N端-SH2 调节亚基结构域；C-SH2：C端-SH2 调节亚基结构域；I-SH2：inter-SH2 调节亚结构域；由于篇幅限制， 本次分享就先到这里，下期文章将继续解析PI3K通路、AKT/PKB介绍和PI3K-AKT信号的下游。参考资料：[1] https://www.creative-diagnostics.com/PI3K-AKT-Signaling-Pathway.htm[2] https://www.genecards.org[3] Fruman, David A., et al. "The PI3K pathway in human disease." Cell 170.4 (2017): 605-635.4 | 本文作者：周老师KEGG的系列文章已经收录到微信公众号：基迪奥生物 #跟周老师一起学KEGG通路 里了如果想先看更多KEGG文章的同学可以到 基迪奥生物 公众号查看专题哦~编辑于 2020-12-25 15:50通路生物信息学基因​赞同 478​​16 条评论​分享​喜欢​收藏​申请

实力靶点AKT：名门将子 破茧待蝶 - 知乎

实力靶点AKT：名门将子 破茧待蝶 - 知乎切换模式写文章登录/注册实力靶点AKT：名门将子 破茧待蝶中肽生化中肽生化是全球一体化多肽/寡核苷酸CRDMO合作伙伴AKT，也称为磷酸激酶B (PKB)，在涉及细胞生长和分裂、细胞凋亡抑制和血管生成的多种级联信号传导机制中发挥着关键作用。同时，AKT也显示出重要的代谢作用，其中包括肌肉和脂肪细胞中的葡萄糖摄取或抑制神经元细胞死亡等。不过，对于处于PI3K/AKT/mTOR关键信号通路中心节点的AKT而言，由于PTEN缺失、AKT/PIK3CA突变或扩增等都会引起AKT信号通路的过度激活，导致肿瘤的发生和发展；近期研究更发现 AKT激活与肿瘤治疗中的耐药性相关。AKT由此成为肿瘤治疗的热门靶标。AKT的发现和功能AKT的名字由来也并非基于它的功能，而是可能反映了AKT信号通路的发现历程。AKT最早可以文献追溯至1977年，来自约翰霍普金斯大学肿瘤学中心的Stephen P. Staal博士在《美国国家科学院院刊》（PANS）上发文称，从自发性淋巴瘤AKR/J小鼠的体外胸腺瘤细胞系AKT8分离到T-8病毒株。10年后，Stephen P. Staal博士再次发表AKT8癌基因及其人类同源物的分子克隆，病毒基因组包含病毒和非病毒的细胞相关序列，非病毒序列被命名为v-akt，推测是AKT8病毒的病毒癌基因。因此，AKT 名字中的“Ak”是指发生自发性胸腺淋巴瘤的AKR小鼠品系，“t”则代表“胸腺瘤”。这也导致后来确定了人源同基因/蛋白时，AKT名字被继续沿用。目前，AKT丝氨酸/苏氨酸激酶家族共发现了三种高度同源的亚型，即AKT1（PKBα）、AKT2（PKBβ）和 AKT3（PKBγ）。AKT三种亚型分别由39个氨基酸铰链区隔开的N端pleckstrin同源 (PH) 域和大的中央激酶域以及C端调节域 (RD) 组成。其中，PH域约有60%的同源性，而激酶结构域的同源性则超过85%。受多种细胞外刺激的刺激，各个AKT成员在不同环境中也具有广泛多样的下游效应。Front. Pharmacol.12:662232在分布表达上，AKT1和AKT2存在较为广泛。其中，AKT1通过抑制细胞凋亡过程参与细胞存活途径，可以阻止细胞凋亡从而促进细胞存活，被认为是许多类型癌症的主要因素。AKT2的表达在褐色脂肪、骨骼肌和肝脏等胰岛素反应组织中升高，是胰岛素信号通路中的重要信号分子，诱导葡萄糖转运；AKT2缺失导致小鼠轻度生长缺陷并表现出糖尿病表型（胰岛素抵抗）。AKT3似乎主要在大脑中表达，虽然也在骨骼肌和肝脏中的表达，但水平较低，其作用不太清楚。在癌细胞中，AKT1 参与增殖和生长，促进肿瘤发生并抑制细胞凋亡；AKT2 调节细胞骨架动力学，有利于侵袭和转移；AKT3 过度激活在癌症中的作用仍然存在争议，尽管其存在刺激细胞增殖的可能。不过，在术语上PKB或AKT可能统称所有三个基因/亚型，但有时也用于单独指代AKT1 / PKBα。AKT1/2/3的主要磷酸化位点分别位于激酶域(T308/T309/T305) 和调节域 (S473/474/472) 中的苏氨酸和丝氨酸残基。AKT激活经历了双重磷酸化，也分别对应着上述激酶结构域（被PDK1磷酸化）和调节域（mTORC2磷酸化）。AKT激活后会磷酸化其下游靶标，包括结节性硬化症复合体 2 (TSC2)、糖原合酶激酶-3β (GSK3β) 和叉头激酶转录因子 (FOXO)，最终促进细胞增殖、代谢和存活。此外，AKT也可以基于ACK1或TNK2在其酪氨酸176残基处的磷酸化，导致其以不依赖PI3-激酶的方式激活。Signal Transductionand Targeted Therapy (2021) 6:425基于肿瘤基因测序的精准肿瘤学试验数据，AKT1-3突变在人类癌症突变中的占比约为3%-5%。其中，E17K是最常见、特征明确的激活突变，但在迄今为止的大型肿瘤测序研究中，E17K仅占AKT1-3突变的15%左右。精准肿瘤学的目的，是将靶向治疗与驱动突变相匹配并避免在临床中使用突变抗性的药物，以提高患者的治疗反应和存活率。常见的E17K突变体和稀有的L52R、Q79K和D323H突变体都清楚地激活并驱动癌症转化。然而，与野生型AKT相比，这些突变体都不会使细胞对变构或ATP竞争性抑制剂更敏感。靶向AKT：耐药治疗新策略AKT相关的基础研究有比较高的学术起点，最早的文献记录是发表在顶级期刊《美国国家科学院院刊》（PANS）上，原型AKT基因于1991年发表在Science杂志上。也是由于一开始奠定的学术研究基础，AKT的转化开发引得众多制药巨头青睐。纵览AKT药物的开发历程，最早介入AKT抑制剂探索和临床开发的公司是葛兰素史克、默沙东、礼来、拜耳，阿斯利康、罗氏(基因泰克)等一众巨头。不过虽然系出名门，但是这些公司开发的AKT抑制剂或者出售，或者研发终止，如礼来的LY2780301、拜耳的BAY1125976等，在一定程度上也说明了新药研发的不确定性以及AKT信号通路的巨大复杂性和挑战性。默沙东的MK-2206，在进行了40多项早期试验后也最终折戟沉沙。一直以来，内在或获得性耐药性是癌症药物疗效无法持续的主要原因，并最终导致治疗失败。因此，随着对潜在机制的不断探索，发现更有前景的药物靶点正成为癌症治疗和预防的最佳治疗方法。PI3K/AKT通路的异常激活以及上游或下游靶标转导，作为负责多种肿瘤形成耐药性的重要信号通路起着至关重要的作用。为了增强肿瘤细胞的敏感性和对抗肿瘤的耐药性，AKT抑制剂在临床研究中也取得一定进展。例如，在乳腺癌中，PI3K/AKT 通路被认为是内分泌治疗耐药性发展的关键参与者，联用AKT抑制剂对抗PI3K/AKT通路的激活，进而通过发挥细胞毒活性来阻止肿瘤细胞的耐药性。因此，阿斯利康、罗氏也在评估单独或组合使用AKT抑制剂，以开发肿瘤治疗新疗法以及应对治疗抗性。来源：医药魔方NextPharma数据库ipatasertib和capivasertib是全球最早进入临床III期开发的AKT抑制剂，适应症主要集中在HR+乳腺癌、三阴性乳腺癌和前列腺癌。2020年，阿斯利康披露了capivasertib联合氟维司群治疗芳香酶抑制剂治疗后复发或进展的HR+/HER2-乳腺癌临床II期数据(FAKTION)。研究结果显示，随机接受氟维司群加capivasertib (n=69) 治疗的患者相较于或氟维司群加安慰剂 (n=71) ，mPFS显著延长（10.3 vs 4.8 m），降低疾病进展风险42%（HR：0·58，95%CI 0.39–0.84），达到研究的主要终点。来凯医药：biotech中的AKT抑制剂开发先行者capivasertib的核心关键注册性临床研究将于明年结束，或许AKT抑制剂的“破茧成蝶”、药物上市的黎明时刻即将到来。在全球biotech企业中，来凯医药在AKT抑制剂afuresertib临床进展最快，已经处于关键的II期注册研究，具有一定的先发优势。来源：医药魔方NextPharma数据库来凯医药优先布局AKT抑制剂与其创始人吕向阳博士的经历不无关系。吕向阳博士毕业于南开大学，在美国北卡罗来纳大学教堂山分校获得生物化学博士学位，并在美国哈佛大学完成博士后，是最早加入诺华生物医学研究中心（Novartis Institutes for BioMedical Research, NIBR）的科学家之一。他在诺华工作过13年，期间带领研发团队完成了二十余项新药研发项目。诺华的两款AKT抑制剂afuresertib和uprosertib最早均由GSK开发，先后完成了卵巢癌、胃癌、多发性骨髓瘤、黑色素瘤等适应症领域的20多项临床I/II期研究，药物的临床疗效和耐受安全性得到初步临床验证。由于GSK与诺华在2014年达成了资产置换协议，Afuresertib和uprosertib随之归诺华所有。不过，诺华当时在肿瘤领域正专注于“变革性”的CAR-T细胞疗法和基因疗法，AKT抑制剂在继续做了4年临床试验之后，犹如K药被收购后的命运一般，被“束之高阁”。其实，诺华研发部门有很多科学家已经看到了AKT激酶选择性抑制剂的潜在价值，其中就包括吕向阳博士。当诺华开始启动对外授权时，来凯医药占据了天时地利人和，先后拿到了afuresertib（LAE002）和uprosertib（LAE003）的权益。尤其值得一提的是，来凯医药拿到的是这两个分子的全球权益，而非部分区域。来凯也由此成为biotech中少有的重点布局AKT抑制剂的公司，属于这个领域的先行者。随之而来的却是适应症选择问题，AKT抑制剂究竟能够解决哪些领域的未满足需求？从来凯医药的产品管线中，我们不难看出，afuresertib（LAE002）选择卵巢癌优先开发。其实，这不仅体现了适应症上的差异化，也确实是符合AKT抑制剂作用机制和临床需求的未满足。在不同瘤种中，卵巢癌都是AKT1-3过表达的优势瘤种。OV：卵巢浆液性囊腺癌（来源：TCGA）浆液性囊腺癌是卵巢恶性肿瘤中最常见的类型。铂类联合紫杉醇类药物当前仍是卵巢癌治疗的首选药物，不过大约10%-15% 的卵巢癌患者对铂化疗无反应；有效患者中，也有80%以上会复发，最终会出现耐药性。上述疗法耐药之后，仅靠非铂类化疗药物治疗，有效性难以令人满意。当然，贝伐珠单抗联合紫杉醇的成功，以及PARP抑制剂临床研究，使联合用药策略成为提高药物敏感性和对抗耐药的潜力策略。然而，贝伐珠单抗+化疗目前仅限于经过不超过2线治疗的患者，在美国，其实际使用仅限于部分的卵巢癌患者，后期的治疗仍然回到化疗。来源：医药魔方DeepMed数据库PI3K/AKT通路的异常激活在多种肿瘤形成耐药性的重要信号通路中起着至关重要的作用，因此，afuresertib选择铂类耐药复发性卵巢癌也算是“理所应当”。临床前的研究显示卵巢癌患者在铂和紫衫醇的治疗中，经常会由于AKT的过分激活而导致耐药，此时抑制AKT可以重新恢复患者对化疗的敏感性。早期的临床试验也令人信服的验证了这一耐药机理，在多线铂治疗耐药的卵巢癌患者中，afuresertib联合卡铂和紫衫醇显示了临床显著的抗肿瘤疗效和良好的安全性。当然，在前列腺癌、三阴乳腺癌，HR+/HER2-乳腺癌领域，afuresertib也并未放弃。针对HR+/HER2-乳腺癌，afuresertib已经在中美两国，获批了一项Ib/III期全球多中心临床研究；抗PD-1/PD-L1耐药的特定实体瘤、三阴乳腺癌也已经推进至I/II期研究。瞄准PD-1/PD-L1耐药2021年7月，来凯医药宣布与信达生物达成合作协议，共同开展afuresertib与信迪利单抗联合用药的临床研究2022年1月，双方合作的治疗抗PD-1/PD-L1耐药特定实体瘤患者的联合治疗方案临床I/II期试验申报，获得了中国国家药品监督管理局药品审评中心（CDE）的批准。此次临床研究瞄准的是当前大热的PD-1/PD-L1肿瘤免疫疗法的耐药性问题。在来凯医药首席医学官岳勇博士看来：尽管具有长期的、潜在的接近于治愈的临床益处，但耐药性仍然是阻碍PD-1/PD-L1疗法进一步应用的重大挑战。因此，免疫抵抗是一种未竟的巨大医疗需求，是提高癌症患者生存率和生活质量的主要障碍之一，而癌细胞中的AKT激活是可能导致免疫抵抗的众多因素之一。联合方案采用三个药物：来凯医药的泛AKT抑制剂——处于临床开发阶段的1类候选新药afuresertib（LAE002）、信达生物的信迪利单抗注射液以及化疗药物白蛋白结合型紫杉醇或多西他赛。来凯医药的泛AKT抑制剂具有潜在的安全性优势，相较于其他临床在研产品的间歇给药方案，afuresertib可以实现口服每日给药。也正是这种安全性优势，使afuresertib更具备联合应用潜力。该项研究的目标旨在I期部分评估上述三种药物联用的安全性、确定II期研究推荐剂量，并在 II 期研究中评估联合治疗的临床有效性和安全性。II 期的研究人群为对既往抗 PD-1/PD-L1 治疗（单药治疗或与其他抗癌药物联合治疗）耐药且患有以下5种选定肿瘤之一的患者：非小细胞肺癌（NSCLC）胃和食管胃结合部腺癌（GC/GEJC）食道癌（EsC）宫颈癌（CC）子宫内膜癌（EC）结语纵观AKT抑制剂的研究进程，不乏崎岖和坎坷。曾经众多跨国巨头的相继进入，似乎也令AKT“风光无二”；先后的折戟沉沙，使AKT抑制剂开发者壮志未酬。得益于阿斯利康、罗氏和来凯医药的坚持与开拓，AKT抑制剂将在2022年再次迎来关键时刻，能否成为“破茧成蝶”的光明时刻，让我们拭目以待。注：原文有删减参考资料[1] What Does the“AKT” Stand for in the Name“AKTKinase”? Some Historical Comments. Comments. Front. Oncol. 10:1329[2] Staal SP, et al. Proc Natl Acad Sci USA.(1977) 74:3065–7; Proc Natl Acad Sci USA. (1987) 84:5034–7[3] AKT Inhibitors: New Weapons in the FightAgainst Breast Cancer? Front. Pharmacol. 12:662232[4] AKT/PKB Signaling: Navigating the Network. Cell 169, 2017: 381[5] Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity. Oncotarget. 2016 Jan26; 7(4): 4241–4251[6] A Portrait of AKT Kinases. Cancer Biology & Therapy 3:3, 268-275[7] AKT inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review). INTERNATIONALJOURNAL OF ONCOLOGY 48: 869-885; The AKT pathway in oncology therapy and beyond.INTERNATIONAL JOURNAL OF ONCOLOGY 53: 2319-2331[8] The AKT/PKB pathway: molecular targetfor cancer drug discovery. Oncogene (2005) 24, 7482–7492[9] AKT/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 40: 30934–30942[10] A. Bellacosa, J.R. Testa, S.P. Staal,P.N. Tsichlis, A retroviral oncogene, AKT, encoding a serine-threonine kinase containing an Sh2-like region. Science 254(1991) 274–277[11] Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY1125976 in Advanced Solid Cancer-Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy. Cancers (Basel). 2019 Dec10;11(12):1987[12] A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9; Safety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose escalation study. Eur J Cancer . 2017 Sep;83:194-202[13] The Pathogenic Role of PI3K/AKT Pathwayin Cancer Onset and Drug Resistance: An Updated Review. Cancers 2021, 13, 3949[14] Fulvestrant plus capivasertib versusplacebo after relapse or progression on an aromatase inhibitor inmetastatic,oestrogen receptor-positive breast cancer (FAKTION):a multicentre,randomised, controlled, phase 2 trial. Lancet Oncol 2020; 21: 345–57[15] Targeting PI3K/Akt signal transductionfor cancer therapy. Signal Transduction and Targeted Therapy (2021) 6:425[16] Innovative therapies to tackleplatinum-resistant ovarian cancer. Nature 600, S45-S47 (2021)免责声明：本文仅作信息交流，文中的观点不代表中肽生化立场，亦不代表中肽生化支持或反对文中观点。本文也不是研究治疗方案推荐。如果需要获得治疗方案指导，请前往正规医院就诊。来源：医药魔方编辑于 2022-01-21 11:20守门员​赞同 21​​添加评论​分享​喜欢​收藏​申请

蛋白激酶B_百度百科

B_百度百科 网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心收藏查看我的收藏0有用+10蛋白激酶B播报讨论上传视频生物学名词蛋白激酶B，即Akt，又称PKB或Rac，在细胞存活和凋亡中起重要作用。胰岛素等生长和存活因子都可以激活Akt信号途径。Akt的Thr308可以被PDK1磷酸化。PI3 Kinase-Akt信号途径是一条经典的信号途径，LY294002等PI3 kinase的抑制剂抑制PI3 kinase时，通常就会抑制Akt激活。中文名称蛋白激酶B英文名称protein kinase B定　　义通过磷酸肌醇被募集到质膜而被激活的一种蛋白丝氨酸/苏氨酸激酶。应用学科细胞生物学（一级学科），细胞化学（二级学科）以上内容由全国科学技术名词审定委员会审定公布中文名蛋白激酶B外文名Akt又称PKB或Rac作用时期细胞存活和凋亡中同源物质PKA和PKC物质简介PKB是一种相对分子约为6.0×10^4的Ser/Thr蛋白激酶，与PKA和PKC均有很高的同源性，故又称为PKA与PKC的相关激酶（related to the A and C kinase,RAC-PK）,该激酶被证明是反转录病毒癌基因v-akt 的编码产物，故又称Akt。新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号 京公网安备110000020000

PI3K Akt 通路 | Cell Signaling Technology

PI3K Akt 通路 | Cell Signaling Technology

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PI3K/Akt 信号转导

PI3K/Akt 信号转导

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通路描述： 自首次发现以来，丝氨酸/苏氨酸激酶 Akt（又称作蛋白激酶 B 或 PKB）作为一种原癌基因，已经成为医学界主要的关注热点，这是因为它在调控各种不同细胞功能（包括代谢、生长、增殖、存活、转录以及蛋白质合成）方面发挥重要作用。能够激活 Akt 信号级联放大的因子，包括受体酪氨酸激酶、整合素、B 细胞和 T 细胞受体、细胞因子受体、G 蛋白偶联受体，以及其他能够通过磷脂酰肌醇三激酶 (PI3K) 诱发三磷酸 (3,4,5)磷脂酰肌醇 (PIP3) 生成的刺激。这些脂质可作为具有普列克底物蛋白同源性(PH) 结构域的蛋白质膜的停泊位点，其中包括 Akt 及其上游激活剂 PDK1。膜上的 PDK1 在 AKt 的苏氨酸 308 位点将其磷酸化，导致 Akt 的部分激活。丝氨酸 473 位点被 mTORC2 磷酸化，可激发Akt 的完全的酶活性。PI3K 相关激酶 (PIKK) 家族成员，包括 DNA-PK，也同样能在 Akt 丝氨酸 473 位点将其磷酸化。Akt 可被蛋白磷酸酶 2A (PP2A) 以及 PH-结构域富含亮氨酸-重复-包含蛋白磷酸酶 (PHLPP1/2)去磷酸化。另外，抑癌基因磷酸酶和张力蛋白同源蛋白(PTEN)，也通过去磷酸化 PIP3 抑制 Akt 活性。 PI3K/Akt 信号通路失调见于多种人类疾病，包括癌症、糖尿病、心血管疾病和神经疾病。在癌症中，已发现两处可增强 PI3K 内在激酶活性的突变。另外，人类肿瘤中 PTEN 常发生突变或缺失。Akt 的活化突变也有报道。Akt 信号转导失调造成人类疾病的频率之高，导致 PI3K 和 Akt 的小分子抑制剂的积极开发达到顶峰。 存在三种高度关联的 Akt 亚型（Akt1、Akt2 和 Akt3），可以将含有共同磷酸化基序 RxRxxS/T 的底物磷酸化。Akt 各亚型可共享多种底物，但也已发现亚型特异性 Akt 底物。例如，所有 Akt 各亚型都能够将 PRAS40（ 分子量为 40 kDa 富含脯氨酸的 Akt底物）磷酸化，但只有 Akt1 能够磷酸化肌动蛋白相关的蛋白 palladin。 Akt 通过作用于 TSC1/TSC2 复合体以及 mTORC 信号转导，进而调节细胞生长。Akt 通过磷酸化 CDK 的抑制剂 p21 和 p27，进而影响细胞增殖。Akt 是细胞存活的主要调节因子，通过直接抑制促凋亡蛋白（如 Bad）或抑制由转录因子（如 FoxO）产生促凋亡信号实现调节。Akt 通过激活 AS160 和 PFKFB2，对调节代谢发挥重要作用。另外，已有证据显示，Akt 可调节参与神经功能的多种蛋白，包括 GABA 受体、ataxin-1 和 huntingtin 蛋白。Akt 通过磷酸化 palladin 和 vimentin，参与细胞迁移和侵袭。Akt 还可以通过磷酸化 IKKα 和 Tpl2，调节 NF-κB 信号转导。由于Akt/PKB 在调节各种细胞功能方面都扮演着重要角色，这使其成为人类疾病治疗的重要靶标。主要文献： Bhaskar PT, Hay N (2007) The two TORCs and Akt. Dev. Cell 12(4), 487–502. Bozulic L, Hemmings BA (2009) PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr. Opin. Cell Biol. 21(2), 256–61. Brugge J, Hung MC, Mills GB (2007) A new mutational AKTivation in the PI3K pathway. Cancer Cell 12(2), 104–7. Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF (2008) The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8(3), 187–98. Hers I, Vincent EE, Tavaré JM (2011) Akt signalling in health and disease. Cell. Signal. 23(10), 1515–27. Liu P, Cheng H, Roberts TM, Zhao JJ (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8(8), 627–44. Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129(7), 1261–74. Salmena L, Carracedo A, Pandolfi PP (2008) Tenets of PTEN tumor suppression. Cell 133(3), 403–14.感谢来自哈佛医学院贝斯以色列女执事医疗中心的 Kristin Brown 和 Alex Toker 教授审核此图。创建于 2007 年 9 月修订时间 2016 年 9 月

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乙酰化酶

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接头蛋白

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2017-08-28

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丝氨酸/苏氨酸激酶 Akt（又称作蛋白激酶 B 或 PKB）作为一种原癌基因，已经成为医学界主要的关注热点，这是因为它在调控各种不同细胞功能（包括代谢、生长、增殖、存活、转录以及蛋白质合成）方面发挥重要作用。能够激活 Akt 信号级联放大的因子，包括受体酪氨酸激酶、整合素、B 细胞和 T 细胞受体、细胞因子受体、G 蛋白偶联受体，以及其他能够通过磷脂酰肌醇三激酶 (PI3K) 诱发三磷酸 (3,4,5) 磷脂酰肌醇 (PIP3) 生成的刺激。这些脂质可作为具有普列克底物蛋白同源性 (PH) 结构域的蛋白质膜的停泊位点，其中包括 Akt 及其上游激活剂 PDK1。膜上的 PDK1 在 AKt 的苏氨酸 308 位点将其磷酸化，导致 Akt 的部分激活。丝氨酸 473 位点被 mTORC2 磷酸化，可激发 Akt 的完全的酶活性。PI3K 相关激酶 (PIKK) 家族成员，包括 DNA-PK，也同样能在 Akt 丝氨酸 473 位点将其磷酸化。Akt 可被蛋白磷酸酶 2A (PP2A) 以及 PH-结构域富含亮氨酸-重复-包含蛋白磷酸酶 (PHLPP1/2) 去磷酸化。另外，抑癌基因磷酸酶和张力蛋白同源蛋白 (PTEN)，也通过去磷酸化 PIP3 抑制 Akt 活性。一、AKT 的背景AKT 是一类 AGC 家族的丝氨酸/苏氨酸激酶，其主要具有 3 个结构域：PH 结构域（对 PIP3 有亲和力，因此对于和胞膜的结合至关重要）；催化结构域；调节结构域。Thr308 和 Ser473 分别位于后两个结构域上，PH 和催化结构域在不同的 Akt 异构体中都是相对比较保守的。哺乳动物中 AKT 有 3 种主要的异构体：Akt1，2，3。Akt1 在组织中有广泛的表达，Akt2 主要在肌肉和脂肪细胞里表达。Akt3 主要在睾丸和脑中表达。随着研究的深入，还发现了一个在疏水结构域存在截短形式的剪切可变体 Akt3-(γ1)，Akt 的磷酸化底物众多，但一般在底物的磷酸化（丝/苏氨酸，S/T）位点附近都有一个保守的基序（motif）序列：R-X-R-X-X-S*/T*，其中 R 代表精氨酸，X 代表任意氨基酸。基于这种保守性，那么借助于这样的 Motif 抗体就为系统地研究 Akt 下游信号通路提供了帮助。二、PI3K 的活化PI3K 可分为 3 类，其结构与功能各异。其中研究最广泛的为 I 类 PI3K, 此类 PI3K 为异源二聚体，由一个调节亚基和一个催化亚基组成。调节亚基含有 SH2 和 SH3 结构域，与含有相应结合位点的靶蛋白相作用。该亚基通常称为 p85, 参考于第一个被发现的亚型 (isotype), 然而目前已知的 6 种调节亚基，大小从 50 至 110kDa 不等。催化亚基有 4 种，即 p110α, β,δ,γ，而δ仅限于白细胞，其余则广泛分布于各种细胞中。PI3K 的活化很大程度上参与到靠近其质膜内侧的底物。多种生长因子和信号传导复合物，包括成纤维细胞生长因子 (FGF)、血管内皮生长因子 (VEGF)、人生长因子 (HGF)、血管位蛋白 I(Ang1) 和胰岛素都能启始 PI3K 的激活过程。这些因子激活受体酪氨酸激酶 (RTK)，从而引起自磷酸化。受体上磷酸化的残基为异源二聚化的 PI3Kp85 亚基提供了一个停泊位点 (docking site)。然而在某些情况下，受体磷酸化则会介导募集一个接头蛋白 (adaptor protein)。比如，当胰岛素激活其受体后，则必须募集一个胰岛素受体底物蛋白 (IRS)，来促进 PI3K 的结合。相似的，当整连蛋白 integrin(非 RTK) 被激活后，粘着斑激酶 (FAK) 则作为接头蛋白，将 PI3K 通过其 p85 停泊。但在以上各情形下，p85 亚基的 SH2 和 SH3 结构域均在一个磷酸化位点与接头蛋白结合。PI3K 募集到活化的受体后，起始多种 PI 中间体的磷酸化。与癌肿尤其相关的 PI3K 转化 PIP2 为 PIP3。三、相关蛋白或基因1.  PI3KPhosphatidylinositide 3-kinases，是一种胞内磷脂酰肌醇激酶。由调节亚基 p85 和催化亚基 p110 构成。与 v．sre 和 v．ras 等癌基因的产物相关。PI3K 本身具有丝氨酸/苏氨酸 (Ser/Thr) 激酶的活性，也具有磷脂酰肌醇激酶的活性。2.  Akt又称 PKB（protein kinase B）。是一种丝氨酸/苏氨酸特异性蛋白激酶，在多种细胞生长过程中发挥关键作用，如葡萄糖代谢、凋亡、细胞增殖、转录和细胞迁移。Akt 的 Ser473 可以被 PDK1 磷酸化。PKB 与 PKA 和 PKC 均有很高的同源性，该激酶被证明是反转录病毒安基因 v-akt  的编码产物，故又称 Akt。3.  mTORMammalian target of rapamycin。mTOR 与其它蛋白质结合，形成两种不同蛋白质复合物，mTOR 复合物 1（mTORC1，）和 mTOR 复合物 2（mTORC2），它们调节不同的细胞过程。mTORC1 由 mTOR、mTOR 调节相关蛋白 Raptor、MLST8 和非核心组分 PRAS40、DEPTOR 组成。mTORC2 由 mTOR、mTOR 帕霉素不敏感伴侣 RICTOR、MLST8 和 mSIN1 组成。两种复合物定位于不同的亚细胞区室，影响它们的活化和功能。4.  AMPKAdenosine 5『-monophosphate (AMP)-activated protein kinase，即 AMP 依赖的蛋白激酶。AMPK 是由α（α1，α2），β（β1，β2）和γ（γ1，γ2，γ3）亚基形成的异三聚体蛋白复合物。虽然在大多数细胞中表达的最常见的是α1，β1 和γ1，但是已经证明α2，β2，γ2 和γ3 也在心肌和骨骼肌中表达。AMPK 的激活：体内 AMP/ATP 比例的升高能激活 AMPK；LKB1 去磷酸化 AMPK 在苏氨酸 172α环位点；CAMKK2 作用在苏氨酸 172 的α环。5.  GSK-3Glycogen synthase kinase 3，糖原合成酶 3。是一种丝氨酸/苏氨酸蛋白激酶。在哺乳动物中，GSK-3 由两个已知的基因 GSK-3α（GSK3A）和 GSK-3β（GSK3B）编码。 GSK-3 涉及许多疾病，包括 II 型糖尿病（2 型糖尿病）、阿尔茨海默氏病、炎症、癌症和双相性精神障碍。GSK-3 通过磷酸化其靶底物上的丝氨酸或苏氨酸残基而发挥功能。6.  PDK-13-phosphoinositide dependent protein kinase-1。对于激活 AKT / PKB 和许多其它 AGC 激酶（包括 PKC，S6K，SGK）是至关重要的。7.  CK2Casein kinase 2，酪蛋白激酶 2。CK2 是丝氨酸/苏氨酸选择性蛋白激酶，其是两个α亚基和两个β亚基的四聚体。CK2 参与细胞周期控制，DNA 修复，调节昼夜节律和其它细胞过程。8.  DNA-PKDNA-dependent protein kinase，DNA 依赖性蛋白激酶。DNA-PK 是由 3 个亚基组成的丝/苏氨酸蛋白激酶，属于 PIKK 家族成员，DNA 损伤的分子传感器。它参与用于 DSB（DNA 双链断裂）修复和 V（D）J 重组的 NHEJ（非同源末端连接）。9.  eNOSEndothelin nictric oxide synthase，内皮型一氧化氮合成酶。一氧化氮合酶有三个亚型，包括神经型一氧化氮合酶（nNOS）、诱导型一氧化氮合酶（iNOS）和内皮型一氧化氮合酶（eNOS）。eNOS 是钙依赖蛋白酶，维持血管的生理功能如血管张力和括约肌松弛等。eNOS 是内皮功能完整标志之一，eNOS 催化合成微量的 NO，能起到保持内皮细胞表面光滑完整，防止血栓形成作用。10.  MELKMaternal embryonic leucine zipper kinase，母体胚胎亮氨酸拉链激酶。Snfl/AMPK 家族中一个独特成员，是一种周期依赖性激酶。研究显示 MELK 与 CDC25B 相互作用。11.  S6 KinaseS6  激酶。RSK（ribosomal s6 kinase，核糖体 s6 激酶）家族成员，参与信号转导。RSK 有两个亚家族，p90rsk（也称为 MAPK 激活蛋白激酶-1，MAPKAP-K1）和 p70rsk（也称为 S6-H1 激酶或简称 S6 激酶）。S6 激酶有两种哺乳动物同源物：S6K1 和 S6K2。12.  PI4KPhosphatidylinositol 4-kinase，磷脂酰肌醇 4-激酶。其催化磷脂酰肌醇 4,5-二磷酸酯生物合成中的第一定向步骤。基于分子量和腺苷的调节，哺乳动物 PI4K 分为 II 型和 III 型两种类型。PI4K 与病毒复制和癌症有关。13.  PIKfyve含有 FYVE 指的磷酸肌醇激酶。PIKfyve 的主要酶活性是将 PtdIns3P 磷酸化成 PtdIns（3,5）P2。参与早期内体的内体载体囊泡生物合成和内膜稳态。14.  PTENPhosphatase and tensin homolog deleted on chromosome ten，人第 10 号染色体缺失的磷酸酶。即 MMAC1（mutated in multiple advanced cancers 1），为一新发现的抑癌基因。属于 PTP（protein tyrosine phosphatases）基因家族成员。PTEN 可能通过去磷酸化参与细胞调控。15.  CREBcAMP response element-binding protein，环磷腺苷效应元件结合蛋白。一种调节基因转录的蛋白质。翻译整理：四正柏题图来源：shutterstock 正版图库

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来源：丁香园

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汇丝氨酸/苏氨酸激酶的AKT代表什么？ - 知乎

汇丝氨酸/苏氨酸激酶的AKT代表什么？ - 知乎首发于生物医药知识聚合社区切换模式写文章登录/注册汇丝氨酸/苏氨酸激酶的AKT代表什么？佰傲谷一般来说生物学的缩写词有很清晰的全称（full name），但有个缩写词却是个例外，这就是汇丝氨酸/苏氨酸激酶——AKT，又名蛋白激酶B (Protein Kinase B, PKB)。在文章中，常常可以看到这样的描述：“The serine/threonine kinase Akt, also known as protein kinase B(PKB), is a central node in cell signaling downstream of growth factors,cytokines, and other cellular stimuli.”PKB的全称都会写出来，但对AKT的全称却避而不谈。那么AKT到底代表什么？如果在中文网站中进行搜索，可发现曾经有人在丁香园论坛提到这个问题，但是仅有2个回答，并且都没有解答AKT到底代表什么。在2020年的一篇考证文章中，加拿大曼尼托巴大学马克斯·拉迪医学院拉迪健康科学学院生理学和病理生理学系Jiuyong Xie博士和德国亚琛RWTH大学医院分子病理生化、实验基因治疗和临床化学研究所（IFMPEGKC）Ralf Weiskirchen博士经过一番调研写道：似乎……名称的起源至少可以解释为：“发现自胸腺瘤细胞系AKT-8的致癌性的逆转录病毒中的癌基因基因编码的丝氨酸/苏氨酸蛋白激酶，而AKT-8细胞系来自洛克菲勒研究所的k.B.Rhoads在C.P.Rhoads博士的实验室里通过近亲繁殖获得的、批号为A的小鼠的K品系小鼠（AKR）。”因此AKT中，AK=批号为A的小鼠的K品系，T=胸腺瘤。AKT代表AKR小鼠的胸腺瘤。这里R代表了洛克菲勒研究院（Rockefeller Institute）。以下是对原文的节译：Akt丝氨酸/苏氨酸激酶家族由三种高度同源的亚型组成，即Akt1（PKBα，OMIM:164730）、Akt2（PKBβ，OMIM:164731）和Akt3（PKBγ，OMIM:611223）。AKT成员通过靶向100多种不同的底物，在不同的环境中具有广泛多样的下游效应。本文根据1933年以来有关文献的记载，对Akt激酶（又称蛋白激酶B或PKB）中Akt的起源进行了解释。1. 约翰霍普金斯肿瘤中心的Stephen P.Staal博士在1987年发表的论文中提到“从AKR小鼠自发性胸腺瘤中分离出一种直接转化的逆转录病毒AKT8。”回溯到10年前，进一步提到T-8病毒株的最初分离物来自“一种体外胸腺瘤细胞系AKT-8，来自一只自发性淋巴瘤性AKR/J小鼠。因此，“AK”很可能来自小鼠名字的“AKR”，“T”代表逆转录病毒细胞来源的“胸腺瘤”，尽管它可能代表病毒的“转化（transforming）”能力。从AKT-8分离的病毒癌基因命名为v-AKT。因此，AKT基因的字母很可能代表相同的意思。2. 洛克菲勒医学研究所的ClaraJ.Lynch博士在1954年的一篇论文中特别解释了小鼠品系的AKR这个名字。她解释说：“现在，根据《近交系小鼠标准命名委员会》的建议，AKR这个称谓代表了一个亚品系，是从AK种群随机交配而来，此后在洛克菲勒研究所这些小鼠的子代继续繁殖。因此，AKR中的“R”应代表洛克菲勒研究所。3. 康奈尔大学医学院和宾夕法尼亚大学的J.Furth博士等人在1933年的一篇论文中解释了“AK”的含义。文章写着：“……我们培育的三种不同品种的小鼠，分别被命名为A、R和S”等。（每种品系的）自交系命名的时候加上第二个小写字母（例如Aa、Ab等，Ra、Rb等）。文章中没有解释A、R等的含义。4. 1991年Staal研究小组克隆了全长v-akt癌基因，并对其进行了测序和生化鉴定。同年，瑞士的Hemmings研究小组和英国的Woodgett研究小组分别分离、测序和鉴定了该癌基因的哺乳动物对应的序列。前者用猪cAMP-PK探针从猪肾LLC-PK1细胞中筛选cDNA文库，然后从人上皮MCF-7或肺成纤维细胞WI38细胞系中分离。后者是利用一个带有简并寡核苷酸引物从人成纤维细胞中扩增出来的，这些引物是根据丝氨酸/苏氨酸蛋白激酶催化结构域中保守的区域设计的。它们被称为rac激酶（related to the A and C kinases）或PKB（与PKC/PKA家族最相似的蛋白激酶B）.参考文献：1. Front. Oncol., 11 August 2020 |https://doi.org/10.3389/fonc.2020.013292. What Does the “AKT” Stand for in the Name“AKT Kinase”? Some Historical Comments发布于 2021-04-21 13:24生物化学洛克菲勒大学 (Rockefeller University)文献​赞同 20​​4 条评论​分享​喜欢​收藏​申请转载​文章被以下专栏收录生物医药知识聚合社区垂直生物科技领域，依托媒体矩阵，为生物制药助

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Akt Antibody | Cell Signaling Technology

Akt Antibody | Cell Signaling Technology

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9272

Akt Antibody

一抗

多克隆抗体

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Primary Antibodies

Akt Antibody

Akt Antibody #9272

Citations (10213)

Filter:

WB

IP

IF

F

Western blot analysis of extracts from CHO cells, transfected with non-targeted (-) or SignalSilence® Akt siRNA I (+) siRNA, using Akt Antibody #9272 and p42 MAP Kinase (Erk2) Antibody #9108. The Akt antibody confirms silencing of protein expression while the p42 MAP Kinase (Erk2) antibody was used to control for loading and specificity of Akt siRNA (A). Phospho-GSK-3β (Ser9) Antibody #9336 was used to confirm downstream pathway inhibition (B).

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Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence® Control siRNA (Fluorescein Conjugate) #6201 (-) or SignalSilence® Akt siRNA I (+), using Akt Antibody #9272 and p42 MAP Kinase (Erk2) Antibody #9108. Akt antibody confirms silencing of Akt expression, while the p42 MAP kinase (Erk2) antibody is used to control for loading and specificity of Akt siRNA.

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Western blot analysis of extracts from NIH/3T3 cells, untreated or PDGF-treated (50 ng/ml) for the indicated times, using Phospho-Akt (Ser473) Antibody #9271 (upper) or Akt Antibody (lower).

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Immunoprecipitation of Akt from HeLa cell extracts. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is Akt Antibody. Western blot was performed using Akt Antibody. Mouse Anti-rabbit IgG (Conformation Specific) (L27A9) mAb #3678 was used as a secondary antibody.

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Confocal immunofluorescent images of C2C12 cells showing nuclear and cytoplasmic localization with Akt Antibody (left, red) compared to an isotype control (right). Actin filaments have been labeled with fluorescein phalloidin.

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Flow cytometric analysis of Jurkat cells using Akt Antibody (solid line) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (dashed line). Anti-rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody.

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Akt Antibody  9272

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WB

IP

IF

F

Western blot analysis of extracts from CHO cells, transfected with non-targeted (-) or SignalSilence® Akt siRNA I (+) siRNA, using Akt Antibody #9272 and p42 MAP Kinase (Erk2) Antibody #9108. The Akt antibody confirms silencing of protein expression while the p42 MAP Kinase (Erk2) antibody was used to control for loading and specificity of Akt siRNA (A). Phospho-GSK-3β (Ser9) Antibody #9336 was used to confirm downstream pathway inhibition (B).

Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence® Control siRNA (Fluorescein Conjugate) #6201 (-) or SignalSilence® Akt siRNA I (+), using Akt Antibody #9272 and p42 MAP Kinase (Erk2) Antibody #9108. Akt antibody confirms silencing of Akt expression, while the p42 MAP kinase (Erk2) antibody is used to control for loading and specificity of Akt siRNA.

Western blot analysis of extracts from NIH/3T3 cells, untreated or PDGF-treated (50 ng/ml) for the indicated times, using Phospho-Akt (Ser473) Antibody #9271 (upper) or Akt Antibody (lower).

Immunoprecipitation of Akt from HeLa cell extracts. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is Akt Antibody. Western blot was performed using Akt Antibody. Mouse Anti-rabbit IgG (Conformation Specific) (L27A9) mAb #3678 was used as a secondary antibody.

Confocal immunofluorescent images of C2C12 cells showing nuclear and cytoplasmic localization with Akt Antibody (left, red) compared to an isotype control (right). Actin filaments have been labeled with fluorescein phalloidin.

Flow cytometric analysis of Jurkat cells using Akt Antibody (solid line) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (dashed line). Anti-rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody.

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Supporting Data

REACTIVITY

H M R Hm Mk C Dm B Dg Pg GP

SENSITIVITY

Endogenous

MW (kDa)

60

SOURCE

Rabbit

Application Key:

WB-Western Blot

IP-Immunoprecipitation

IHC-Immunohistochemistry

ChIP-Chromatin Immunoprecipitation

C&R-CUT&RUN

C&T-CUT&Tag

DB-Dot Blot

eCLIP-eCLIP

IF-Immunofluorescence

F-Flow Cytometry

Species Cross-Reactivity Key:

H-Human

M-Mouse

R-Rat

Hm-Hamster

Mk-Monkey

Vir-Virus

Mi-Mink

C-Chicken

Dm-D. melanogaster

X-Xenopus

Z-Zebrafish

B-Bovine

Dg-Dog

Pg-Pig

Sc-S. cerevisiae

Ce-C. elegans

Hr-Horse

GP-Guinea Pig

Rab-Rabbit

All-All Species Expected

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Product Information

Product Usage Information

Application

Dilution

Western Blotting

1:1000

Immunoprecipitation

1:50

Immunofluorescence (Immunocytochemistry)

1:200

Flow Cytometry (Fixed/Permeabilized)

1:50 - 1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Select your Protocol

Western Blotting

Immunoprecipitation

Immunofluorescence (Immunocytochemistry)

Flow Cytometry (Fixed/Permeabilized)

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Western Blotting Protocol

For western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight.

NOTE: Please refer to primary antibody product webpage for recommended antibody dilution.

A. Solutions and Reagents

From sample preparation to detection, the reagents you need for your Western Blot are now in one convenient kit: #12957 Western Blotting Application Solutions Kit

NOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.

20X Phosphate Buffered Saline (PBS): (#9808) To prepare 1 L 1X PBS: add 50 ml 20X PBS to 950 ml dH2O, mix.

10X Tris Buffered Saline (TBS): (#12498) To prepare 1 L 1X TBS: add 100 ml 10X to 900 ml dH2O, mix.

1X SDS Sample Buffer: Blue Loading Pack (#7722) or Red Loading Pack (#7723) Prepare fresh 3X reducing loading buffer by adding 1/10 volume 30X DTT to 1 volume of 3X SDS loading buffer. Dilute to 1X with dH2O.

10X Tris-Glycine SDS Running Buffer: (#4050) To prepare 1 L 1X running buffer: add 100 ml 10X running buffer to 900 ml dH2O, mix.

10X Tris-Glycine Transfer Buffer: (#12539) To prepare 1 L 1X Transfer Buffer: add 100 ml 10X Transfer Buffer to 200 ml methanol + 700 ml dH2O, mix.

10X Tris Buffered Saline with Tween® 20 (TBST): (#9997) To prepare 1 L 1X TBST: add 100 ml 10X TBST to 900 ml dH2O, mix.

Nonfat Dry Milk: (#9999).

Blocking Buffer: 1X TBST with 5% w/v nonfat dry milk; for 150 ml, add 7.5 g nonfat dry milk to 150 ml 1X TBST and mix well.

Wash Buffer: (#9997) 1X TBST.

Bovine Serum Albumin (BSA): (#9998).

Primary Antibody Dilution Buffer: 1X TBST with 5% BSA; for 20 ml, add 1.0 g BSA to 20 ml 1X TBST and mix well.

Biotinylated Protein Ladder Detection Pack: (#7727).

Blue Prestained Protein Marker, Broad Range (11-250 kDa): (#59329).

Blotting Membrane and Paper: (#12369) This protocol has been optimized for nitrocellulose membranes. Pore size 0.2 µm is generally recommended.

Secondary Antibody Conjugated to HRP: Anti-rabbit IgG, HRP-linked Antibody (#7074).

Detection Reagent: SignalFire™ ECL Reagent (#6883).

B. Protein Blotting

A general protocol for sample preparation.

Treat cells by adding fresh media containing regulator for desired time.

Aspirate media from cultures; wash cells with 1X PBS; aspirate.

Lyse cells by adding 1X SDS sample buffer (100 µl per well of 6-well plate or 500 µl for a 10 cm diameter plate). Immediately scrape the cells off the plate and transfer the extract to a microcentrifuge tube. Keep on ice.

Sonicate for 10–15 sec to complete cell lysis and shear DNA (to reduce sample viscosity).

Heat a 20 µl sample to 95–100°C for 5 min; cool on ice.

Microcentrifuge for 5 min.

Load 20 µl onto SDS-PAGE gel (10 cm x 10 cm).

NOTE: Loading of prestained molecular weight markers (#59329, 10 µl/lane) to verify electrotransfer and biotinylated protein ladder (#7727, 10 µl/lane) to determine molecular weights are recommended.

Electrotransfer to nitrocellulose membrane (#12369).

C. Membrane Blocking and Antibody Incubations

NOTE: Volumes are for 10 cm x 10 cm (100 cm2) of membrane; for different sized membranes, adjust volumes accordingly.

I. Membrane Blocking

(Optional) After transfer, wash nitrocellulose membrane with 25 ml TBS for 5 min at room temperature.

Incubate membrane in 25 ml of blocking buffer for 1 hr at room temperature.

Wash three times for 5 min each with 15 ml of TBST.

II. Primary Antibody Incubation

Incubate membrane and primary antibody (at the appropriate dilution and diluent as recommended in the product webpage) in 10 ml primary antibody dilution buffer with gentle agitation overnight at 4°C.

Wash three times for 5 min each with 15 ml of TBST.

Incubate membrane with Anti-rabbit IgG, HRP-linked Antibody (#7074 at 1:2000) and anti-biotin, HRP-linked Antibody (#7075 at 1:1000–1:3000) to detect biotinylated protein markers in 10 ml of blocking buffer with gentle agitation for 1 hr at room temperature.

Wash three times for 5 min each with 15 ml of TBST.

Proceed with detection (Section D).

D. Detection of Proteins

Directions for Use:

Wash membrane-bound HRP (antibody conjugate) three times for 5 minutes in TBST.

Prepare 1X SignalFire™ ECL Reagent (#6883) by diluting one part 2X Reagent A and one part 2X Reagent B (e.g. for 10 ml, add 5 ml Reagent A and 5 ml Reagent B). Mix well.

Incubate substrate with membrane for 1 minute, remove excess solution (membrane remains wet), wrap in plastic and expose to X-ray film.

* Avoid repeated exposure to skin.

posted June 2005

revised June 2020

Protocol Id: 10

Immunoprecipitation for Native Proteins

This protocol is intended for immunoprecipitation of native proteins utilizing Protein A agarose beads for analysis by western immunoblot or kinase activity.

A. Solutions and Reagents

NOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.

20X Phosphate Buffered Saline (PBS): (#9808) To prepare 1 L of 1X PBS, add 50 ml 20X PBS to 950 ml dH2O, mix.

10X Cell Lysis Buffer: (#9803) To prepare 10 ml of 1X cell lysis buffer, add 1 ml cell lysis buffer to 9 ml dH2O, mix.

NOTE: Add 1 mM PMSF (#8553) immediately prior to use.

3X SDS Sample Buffer: Blue Loading Pack (#7722) or Red Loading Pack (#7723) Prepare fresh 3X reducing loading buffer by adding 1/10 volume 30X DTT to 1 volume of 3X SDS loading buffer.

Protein A Agarose Beads: (#9863).

10X Kinase Buffer (for kinase assays): (#9802) To Prepare 1 ml of 1X kinase buffer, add 100 µl 10X kinase buffer to 900 µl dH2O, mix.

ATP (10 mM) (for kinase assays): (#9804) To prepare 0.5 ml of ATP

(200 µM), add 10 µl ATP (10 mM) to 490 µl 1X kinase buffer.

B. Preparing Cell Lysates

Aspirate media. Treat cells by adding fresh media containing regulator for desired time.

To harvest cells under nondenaturing conditions, remove media and rinse cells once with ice-cold 1X PBS.

Remove PBS and add 0.5 ml ice-cold 1X cell lysis buffer to each plate (10 cm) and incubate on ice for 5 min.

Scrape cells off the plate and transfer to microcentrifuge tubes. Keep on ice.

Sonicate on ice three times for 5 sec each.

Microcentrifuge for 10 min at 4°C, 14,000 x g and transfer the supernatant to a new tube. The supernatant is the cell lysate. If necessary, lysate can be stored at -80°C.

C. Immunoprecipitation

Cell Lysate Pre-Clearing (Optional)

Vortex to mix beads.

Add 10–30 µl of 50% Protein A agarose bead slurry to 200 µl cell lysate at 1 mg/ml.

Incubate with rotation at 4°C for 30–60 min.

Microcentrifuge for 10 min at 4°C. Transfer the supernatant to a fresh tube.

Proceed to immunoprecipitation below.

Immunoprecipitation

IMPORTANT: Appropriate isotype controls are highly recommended in order to show specific binding in your primary antibody immunoprecipitation. Use Normal Rabbit IgG #2729 for rabbit polyclonal primary antibodies, Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 for rabbit monoclonal primary antibodies, Mouse (G3A1) mAb IgG1 Isotype Control #5415 for mouse monoclonal IgG1 primary antibodies, Mouse (E5Y6Q) mAb IgG2a Isotype Control #61656 for mouse monoclonal IgG2a primary antibodies, Mouse (E7Q5L) mAb IgG2b Isotype Control #53484 for mouse monoclonal IgG2b primary antibodies, and Mouse (E1D5H) mAb IgG3 Isotype Control #37988 for mouse monoclonal IgG3 primary antibodies. Isotype controls should be concentration matched and run alongside the primary antibody samples.

Add primary antibody (at the appropriate dilution as recommended in the product datasheet) to 200 µl cell lysate at 1 mg/ml. Incubate with rotation overnight at 4°C.

Add protein A agarose (10–30 µl of 50% bead slurry). Incubate with rotation for 1–3 hr at 4°C.

Microcentrifuge for 30 sec at 4°C. Wash pellet five times with 500 µl of 1X cell lysis buffer. Keep on ice between washes.

Proceed to sample analysis by western immunoblotting or kinase activity (section D).

D. Sample Analysis

Proceed to one of the following specific set of steps.

For Analysis by Western Immunoblotting

Resuspend the pellet with 20 µl 3X SDS sample buffer. Vortex, then microcentrifuge for 30 sec at 14,000 x g.

Heat the sample to 95–100°C for 2-5 min and microcentrifuge for 1 min at 14,000 x g.

Load the sample (15–30 µl) on a 4–20% gel for SDS-PAGE.

Analyze sample by western blot (see Western Immunoblotting Protocol).

NOTE: When using primary antibodies produced in rabbit to detect proteins with a molecular weight in the range of 50 kDa, we recommend using Mouse Anti-Rabbit IgG (Light-Chain Specific) (D4W3E) mAb (#45262) or Mouse Anti-Rabbit IgG (Conformation Specific) (L27A9) mAb (#3678) (or HRP conjugate #5127) as a secondary antibody to minimize interference produced by denatured rabbit heavy chain. For proteins with a molecular weight in the range of 25 kDa, Mouse Anti-Rabbit IgG (Conformation Specific) (L27A9) mAb (#3678) (or HRP conjugate #5127) is recommended to minimize interference produced by denatured mouse light chain.

When using primary antibodies produced in mouse to detect proteins with a molecular weight in the range of 50 kDa, we recommend using Rabbit Anti-Mouse IgG (Light Chain Specific) (D3V2A) mAb (HRP Conjugate) (#58802) as a secondary antibody to minimize interference produced by denatured mouse heavy chain.

For Analysis by Kinase Assay

Wash pellet twice with 500 µl 1X kinase buffer. Keep on ice.

Suspend pellet in 40 µl 1X kinase buffer supplemented with 200 µM ATP and appropriate substrate.

Incubate for 30 min at 30°C.

Terminate reaction with 20 µl 3X SDS sample buffer. Vortex, then microcentrifuge for 30 sec.

Transfer supernatant containing phosphorylated substrate to another tube.

Heat the sample to 95–100°C for 2–5 min and microcentrifuge for 1 min at 14,000 x g.

Load the sample (15–30 µl) on SDS-PAGE (4–20%).

posted December 2008

revised October 2021

Protocol Id: 409

Immunofluorescence (Immunocytochemistry)

A. Solutions and Reagents

Achieve higher quality immunofluorescent images using the efficient and cost-effective, pre-made reagents in our #12727 Immunofluorescence Application Solutions Kit

NOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.

20X Phosphate Buffered Saline (PBS): (9808) To prepare 1L 1X PBS: add 50 ml 20X PBS to 950 ml dH2O, mix. Adjust pH to 8.0.

Formaldehyde: 16%, methanol free, Polysciences, Inc. (cat# 18814), use fresh and store opened vials at 4°C in dark, dilute in 1X PBS for use.

Blocking Buffer (1X PBS / 5% normal serum / 0.3% Triton™ X-100): To prepare 10 ml, add 0.5 ml normal serum from the same species as the secondary antibody (e.g., Normal Goat Serum (#5425)) and 0.5 mL 20X PBS to 9.0 mL dH2O, mix well. While stirring, add 30 µl Triton™ X-100.

Antibody Dilution Buffer (1X PBS / 1% BSA / 0.3% Triton X-100): To prepare 10 ml, add 30 µl Triton™ X-100 to 10 ml 1X PBS. Mix well then add 0.1 g BSA (9998), mix.

Recommended Fluorochrome-conjugated Anti-Rabbit secondary antibodies:

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate) #4412

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 555 Conjugate) #4413

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 594 Conjugate) #8889

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 647 Conjugate) #4414

Prolong® Gold AntiFade Reagent (#9071), Prolong® Gold AntiFade Reagent with DAPI (#8961).

B. Specimen Preparation - Cultured Cell Lines (IF-IC)

NOTE: Cells should be grown, treated, fixed and stained directly in multi-well plates, chamber slides or on coverslips.

Aspirate liquid, then cover cells to a depth of 2–3 mm with 4% formaldehyde diluted in 1X PBS.

NOTE: Formaldehyde is toxic, use only in a fume hood.

Allow cells to fix for 15 min at room temperature.

Aspirate fixative, rinse three times in 1X PBS for 5 min each.

Proceed with Immunostaining (Section C).

C. Immunostaining

NOTE: All subsequent incubations should be carried out at room temperature unless otherwise noted in a humid light-tight box or covered dish/plate to prevent drying and fluorochrome fading.

Block specimen in Blocking Buffer for 60 min.

While blocking, prepare primary antibody by diluting as indicated on product webpage in Antibody Dilution Buffer.

Aspirate blocking solution, apply diluted primary antibody.

Incubate overnight at 4°C.

Rinse three times in 1X PBS for 5 min each.

Incubate specimen in fluorochrome-conjugated secondary antibody diluted in Antibody Dilution Buffer for 1–2 hr at room temperature in the dark.

Rinse three times in 1X PBS for 5 min each.

Coverslip slides with Prolong® Gold Antifade Reagent (#9071) or Prolong® Gold Antifade Reagent with DAPI (#8961).

For best results, allow mountant to cure overnight at room temperature. For long-term storage, store slides flat at 4°C protected from light.

posted November 2006

revised November 2013

Protocol Id: 24

Flow Cytometry, Methanol Permeabilization Protocol for Rabbit

Antibodies

A. Solutions and Reagents

All reagents required for this protocol may be efficiently purchased together in our Intracellular Flow

Cytometry Kit (Methanol) #13593, or

individually using the catalog numbers listed below.

NOTE: Prepare solutions with reverse osmosis deionized (RODI) or equivalent grade water.

1X Phosphate Buffered Saline (PBS): To prepare 1 L 1X PBS: add 100 ml 10X PBS (#12528) to 900 ml water mix.

4% Formaldehyde, Methanol-Free (#47746)

100% Methanol (#13604): Chill before use

Antibody Dilution Buffer: Purchase ready-to-use Flow Cytometry Antibody Dilution Buffer (#13616), or prepare a 0.5% BSA PBS buffer by

dissolving 0.5 g Bovine Serum Albumin (BSA) (#9998) in 100 ml 1X PBS. Store at 4°C.

Recommended Anti-Rabbit secondary antibodies::

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate) #4412

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 594 Conjugate) #8889

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 647 Conjugate) #4414

Anti-Rabbit IgG (H+L), F(ab')2 Fragment (PE Conjugate) #79408

NOTE: When including fluorescent cellular dyes in your experiment (including viability dyes, DNA dyes, etc.), please refer to the dye product page for the recommended protocol. Visit www.cellsignal.com for a full listing of cellular dyes validated for use in flow cytometry.

B. Fixation

NOTE: Adherent cells or tissue should be dissociated and in single-cell suspension prior to fixation.

NOTE: Optimal centrifugation conditions will vary depending upon cell type and reagent volume. Generally, 150-300g for 1-5 minutes will be sufficient to pellet the cells.

NOTE: If using whole blood, lyse red blood cells and wash by centrifugation prior to fixation.

NOTE: Antibodies targeting CD markers or other extracellular proteins may be added prior to fixation if the epitope is disrupted by formaldehyde and/or methanol. The antibodies will remain bound to the target of interest during the fixation and permeabilization process. However, note that some fluorophores (including PE and APC) are damaged by methanol and thus should not be added prior to permeabilization. Conduct a small-scale experiment if you are unsure.

Pellet cells by centrifugation and remove supernatant.

Resuspend cells in approximately 100 µl 4% formaldehyde per 1 million cells. Mix well to dissociate pellet and prevent cross-linking of individual cells.

Fix for 15 min at room temperature (20-25°C).

Wash by centrifugation with excess 1X PBS. Discard supernatant in appropriate waste container. Resuspend cells in 0.5-1 ml 1X PBS. Proceed to Permeabilization step.

Alternatively, cells may be stored overnight at 4°C in 1X PBS.

C. Permeabilization

Permeabilize cells by adding ice-cold 100% methanol slowly to pre-chilled cells, while gently vortexing, to a final concentration of 90% methanol.

Permeabilize for a minimum of 10 min on ice.

Proceed with immunostaining (Section D) or store cells at -20°C in 90% methanol.

D. Immunostaining

NOTE: Count cells using a hemocytometer or alternative method.

Aliquot desired number of cells into tubes or wells. (Generally, 5x105 to 1x106 cells per assay.)

Wash cells by centrifugation in excess 1X PBS to remove methanol. Discard supernatant in appropriate

waste container. Repeat if necessary.

Resuspend cells in 100 µl of diluted primary antibody, prepared in Antibody Dilution Buffer at a recommended dilution or as determined via titration.

Incubate for 1 hr at room temperature.

Wash by centrifugation in Antibody Dilution Buffer or 1X PBS. Discard supernatant. Repeat.

Resuspend cells in 100 µl of diluted fluorochrome-conjugated secondary antibody (prepared in Antibody Dilution Buffer at the recommended dilution).

Incubate for 30 min at room temperature. Protect from light.

Wash by centrifugation in Antibody Dilution Buffer or 1X PBS. Discard supernatant. Repeat.

Resuspend cells in 200-500 µl of 1X PBS and analyze on flow cytometer.

posted July 2009

revised June 2020

实验步骤编号：404

特异性/灵敏度

Akt Antibody 可检测 Akt1、Akt2 和 Akt3 总蛋白的内源水平。抗体不与相关激酶发生交叉反应。

物种反应性：

人, 小鼠, 大鼠, 仓鼠 , 猴, 鸡 , 黑腹果蝇 , 牛 , 犬 , 猪 , 豚鼠

基于 100% 序列同源性预测发生反应的物种：

用于生产此抗体的抗原序列与此处列出的物种具有 100% 的序列同源性，但 CST 尚未测试或确认其反应性有效。将本产品与这些物种一起使用不在我们的抗体性能保证范围内。

犬

来源/纯化

通过采用与小鼠 Akt 的羧基末端序列相对应的合成肽对动物进行免疫接种来产生多克隆抗体。通过蛋白质 A 和肽亲和色谱纯化抗体。

背景

Akt 也称作 PKB 或 Rac，在控制细胞存活和凋亡中发挥至关重要作用 (1-3)。这种蛋白激酶由胰岛素和多种生长和存活因子激活，并在涉及 PI3 激酶的 wortmannin 敏感通路中发挥作用 (2,3)。通过磷脂结合过程并由 PDK1 在 Thr308 位点磷酸化激活环 (4) ，以及通过羧基末端内部 Ser473 处的磷酸化激活 Akt。曾经功能难以捉摸的 PDK2 可在 Ser473 处磷酸化 Akt ，它被鉴定为在含 rictor 和 Sin1 的雷帕霉素中的非敏感复合体中哺乳动物雷帕霉素靶标 (mTOR) (5,6)。Akt 通过磷酸化和失活几种靶标（包括 Bad (7)、叉头转录因子 (8)、c-Raf (9) 和 caspase-9）而抑制凋亡，进而促进细胞存活。PTEN 磷酸酶是 PI3K/Akt 信号转导通路的主要负向调节分子 (10)。LY294002 是特异性 PI3 激酶抑制剂 (11)。Akt 的另一个主要功能是通过磷酸化和失活 GSK-3α 和 β 调节糖原合成 (12,13)。Akt 还可以在胰岛素刺激转运葡萄糖中发挥作用 (12)。除其在存活和糖原合成中的作用外，Akt 还通过防止 GSK-3β 介导的磷酸化和周期蛋白 D1 降解 (14) 并通过负向调节周期蛋白依赖性激酶抑制蛋白 p27 Kip1 (15) 和 p21 Waf1/Cip1 (16) 来参与细胞周期调节。Akt 还通过直接磷酸化含有 raptor 的雷帕霉素敏感性复合体中的 mTOR，在细胞生长中发挥至关重要作用 (17)。更重要的是，Akt 磷酸化并失活结节蛋白 (TSC2)（在 mTOR-raptor 复合体中 mTOR 的抑制分子）(18,19)。

Franke, T.F. et al. (1997) Cell 88, 435-7.

Burgering, B.M. and Coffer, P.J. (1995) Nature 376, 599-602.

Franke, T.F. et al. (1995) Cell 81, 727-36.

Alessi, D.R. et al. (1996) EMBO J 15, 6541-51.

Sarbassov, D.D. et al. (2005) Science 307, 1098-101.

Jacinto, E. et al. (2006) Cell 127, 125-37.

Cardone, M.H. et al. (1998) Science 282, 1318-21.

Brunet, A. et al. (1999) Cell 96, 857-68.

Zimmermann, S. and Moelling, K. (1999) Science 286, 1741-4.

Cantley, L.C. and Neel, B.G. (1999) Proc Natl Acad Sci USA 96, 4240-5.

Vlahos, C.J. et al. (1994) J Biol Chem 269, 5241-8.

Hajduch, E. et al. (2001) FEBS Lett 492, 199-203.

Cross, D.A. et al. (1995) Nature 378, 785-9.

Diehl, J.A. et al. (1998) Genes Dev 12, 3499-511.

Gesbert, F. et al. (2000) J Biol Chem 275, 39223-30.

Zhou, B.P. et al. (2001) Nat Cell Biol 3, 245-52.

Navé, B.T. et al. (1999) Biochem J 344 Pt 2, 427-31.

Inoki, K. et al. (2002) Nat Cell Biol 4, 648-57.

Manning, B.D. et al. (2002) Mol Cell 10, 151-62.

通路

探索与本品相关的通路。

选择您的通路

AMPK 信号转导

黏附连接动力学

阿尔茨海默病

血管生成

凋亡调控

B 细胞受体信号转导

ESC 多能性和分化

ErbB/HER 信号传导

G1/S 检查点

IL6 信号转导

凋亡的抑制

胰岛素受体信号转导

微管动力学

凋亡的线粒体控制

NF-kB 信号转导

PI3K/Akt 信号转导

蛋白激酶 C 信号转导

T 细胞受体信号转导

TGF-ß 信号转导

翻译：eIF4E 和 p70S6K

Warburg 效应

mTOR 信号转导

×

上游 / 下游蛋白质

STRING - 已知和预测的蛋白质间相互作用。

关闭

数据库链接

UniProt ID：

P31751

， Q9Y243

， P31749

Entrez-Gene Id:

208

, 10000

, 207

在 PhosphoSitePlus® 中查看

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PI3K/Akt 底物表

PI3K/Akt 底物表

PI3K/Akt 底物表提供一份经证明的 Akt 磷酸化下游靶标的完整清单，以及相应的磷酸化位点、出版物参考以及磷酸化的作用。该信息使用 PhosphoSitePlus® 生成，后者是 CST 在网站（网址为 www.phosphosite.org）上提供的有关蛋白修饰信息的公开科学资源。

底物

同工型

生物

位点

人体位点

序列 (+/-）

PMID

底物功能和磷酸化作用

14-3-3 z

Akt1

人

S58

S58

VVGARRSsWRVVssI

11956222

信号转导、检查点控制、凋亡以及营养感应通道的一种关键调节蛋白；磷酸化的作用未知

acinus

Akt1

人

S1180

S1180

GPRsRsRsRDRRRKE

18559500, 16177823

在凋亡期间诱导染色质凝聚；磷酸化会抑制这个过程

 

Akt1

大鼠

S1329

S1331

HSRSRSRsTPVRDRG

16177823

ACLY

Akt1

小鼠

S455

S455

PAPSRtAsFsESRAD

16007201

催化细胞质中乙酰基 CoA 和草酰乙酸盐 (OAA) 的形成；磷酸化会增加酶的催化活性

ADRB2

Akt1

人

S346

S346

LLCLRRssLKAyGNG

11809767

一种结合肾上腺素和去甲肾上腺素的受体，可作为中枢神经系统的一种神经调节物质以及血管系统的激素；磷酸化在胰岛素刺激下会隔离 ADBR2

Akt1

Akt1

人

S246, T72

S246, T72

LSRERVFsEDRARFY, TERPRPNtFIIRCLQ

16549426

经胰岛素以及不同的生长和存活因子激活，在 wortmannin 敏感的 PI3 激酶参与的通路中发挥作用，控制存活和凋亡；自磷酸化会激活激酶

 

Akt1

小鼠

S473

S473

RPHFPQFsYsAsGtA

11570877, 10722653

AMPKA1

Akt1

大鼠

S485

S485

ATPQRSGsISNYRSC

16340011

在能量平衡调节中起到关键作用的异二聚体复合体；磷酸化可调节 AMPK 活性

AMPKA2

Akt1

大鼠

S491

S491

STPQRSCsAAGLHRP

16340011

在能量平衡调节中起到关键作用的异二聚体复合体；磷酸化可调节 AMPK 活性

APS

Akt1

大鼠

S588

S598

SARSRSNsTEHLLEA

16141217

一种被募集至胰岛素受体，以转导胰岛素刺激的葡萄糖转运信号的接头蛋白；磷酸化会促进膜定位

AR

Akt1

人

S213, S791

S213, S791

SGRAREAsGAPTsSK, CVRMRHLsQEFGWLQ

11404460, 14555644, 17470458, 11156376

核受体；磷酸化会抑制 AR 激活、AR 靶标基因的表达以及 AR 介导的凋亡

arfaptin 2

Akt1

人

S260

S260

GTRGRLEsAQATFQA

15809304

ADP 核糖基化因子 - 相互作用蛋白，作为亨廷顿氏舞蹈病的中一个因素；磷酸化会促进神经细胞存活和神经保护

ARHGAP22

Akt1

人

S16

S16

ARRARSKsLVMGEQS

21969604

一种可抑制 Rac1 的 Rho GTP 酶激活剂；磷酸化可实现 14-3-3 结合以及细胞运动性的调节

AS160

Akt1

人

T642

T642

QFRRRAHtFsHPPss

16880201, 11994271, 16935857

胰岛素刺激的 Rab GTP 酶激活蛋白，在结构和功能上与 TBC1D1 相似；磷酸化会导致 Glut4 转位增加

ASK1

Akt1, Akt2

人

S83

S83

ATRGRGssVGGGSRR

11154276, 15782121, 15911620, 14500571, 12697749

MAPKKK，通过 JNK 通路诱导凋亡；磷酸化会抑制活性并促进存活

ataxin-1

Akt1

人

S775

S775

ATRKRRWsAPESRKL

17540008, 12757707

14-3-3结合 ataxin-1 并使之稳定，形成多聚谷氨酰胺聚合物和神经退行性疾病；磷酸化可促进 14-3-3 结合

B-Raf

Akt1, Akt3

人

S365, S429

S365, S429

GQRDRsssAPNVHIN, PQRERKsssSsEDRN

10869359, 18451171

信号转导 Erk1/2 通路介质；磷酸化会导致产生抑制作用

BAD

Akt1

人

S99

S99

PFRGRsRsAPPNLWA

11020382, 10558990, 19667065

促凋亡蛋白；磷酸化会抑制功能并促进存活

Akt1

小鼠

S112, S155

S75, S118

ETRsRHssyPAGtEE, GRELRRMsDEFEGSF

9381178, 11723239, 10983986, 15123689, 10949026

Bcl-10

Akt1

人

S218, S231

S218, S231

EEGTCANsSEMFLPL, PLRSRtVsRQ_____

16280327

CARD（Caspase 募集结构域），包含能够诱导凋亡并激活 NF-κB 的蛋白 ；磷酸化会诱导核转位

Bcl-xL

Akt1

大鼠

S106

S106

LRYRRAFsDLTSQLH

18951975

可通过结合凋亡蛋白防止凋亡；磷酸化可促进 VDAC 结合

Bex1

Akt1

大鼠

S105

S102

KLRERQLsHSLRAVS

16498402

一种神经营养因子和神经生长因子信号中的接头分子，可以促进细胞周期进程；磷酸化可通过防止被蛋白酶体降解

Bim

Akt1

人

S87

S87

FIFMRRssLLSRSss

16282323

促凋亡蛋白；磷酸化可促进 14-3-3 结合/失活和细胞存活

BRCA1

Akt1

人

S694, T509

S694, T509

QTSKRHDsDTFPELK, LKRKRRPtsGLHPED

20085797, 10542266

乳腺癌易感基因产物、抑癌基因；磷酸化可能通过防止核定位来改变功能

BRF1

Akt1

人

S92, S203

S92, S203

RFRDRsFsEGGERLL, PRLQHsFsFAGFPSA

17030608, 15538381

一种 CCCH 锌指蛋白，它结合在 mRNA 的 3' 未翻译区域中发现的 AU 富集序列 (ARE)，并通过外来体促进去腺苷酰和快速降解；磷酸化会导致与 14-3-3 蛋白结合并使 BRF1 失活

CACNB2

Akt1

大鼠

S625

S630

KQRSRHKsKDRYCDK

15311280

电压依赖性钙通道；磷酸化可调节转运至质膜的通道

CaRHSP1

Akt1

人

S52

S52

tRRtRtFsAtVRASQ

15910284

RNA 结合蛋白；磷酸化作用目前未知

Casp9

Akt1

人

S196

S196

KLRRRFssLHFMVEV

9812896

启动凋亡的蛋白酶；磷酸化会抑制蛋白酶活性

CBP

Akt1

小鼠

T1872

T1871

LMRRRMAtMNTRNVP

17166829

乙酰化组蛋白和非组蛋白；磷酸化可增强活性

CBY1

Akt1, Akt2

人

S20

S20

TPPRKSAsLSNLHsL

18573912

Wnt 信号转导通路的一种抑制剂；磷酸化可实现细胞浆中 14-3-3 的结合以及 β-链蛋白的隔离

CCT2

Akt1

人

S260

S260

GsRVRVDstAkVAEI

19332537

蛋白质分子伴侣复合体的成员；磷酸化的作用目前未知

CD34

Akt2

小鼠

S343

S346

yssGPGAsPETQGKA

21499536

一种 I 型跨膜磷酸化糖蛋白，由造血干细胞/祖细胞、血管内皮和一些成纤维细胞表达，可作为细胞黏附的负调节分子；磷酸化的作用目前未知

Cdc25B

Akt1

小鼠

S351

S353

VQSKRRKsVtPLEEQ

17554083

负责 cdc2 激活的蛋白磷酸酶；磷酸化可促进 M 期促进因子的激活

CDK2

Akt1

人

T39

T39

LkKIRLDtETEGVPs

18354084

在 S 期起作用的周期素依赖性激酶；磷酸化可促进周期素 A 的结合

CELF1

Akt1

人

S28

S28

GQVPRTWsEKDLREL

18570922

RNA 结合蛋白；磷酸化可增强与周期素 D1 mRNA 的相互作用

CENTB1

Akt1

人

S554

S554

SIRPRPGsLRSKPEP

16256741

作为 ARF 蛋白的 GTP 酶激活蛋白 (GAP)；磷酸化会防止 b1 整合素的循环，包括内体和细胞迁移

CENTG1

Akt1

人

S985

S985

THLSRVRsLDLDDWP

19176382

一种作为 ARF1 和 ARF5 的 GTP 酶激活蛋白；磷酸化可增强 CENTG1 GTP 结合和 NF-κB 活性

CFLAR

Akt1

人

S273

S273

LLRDTFTsLGYEVQK

19339247

一种凋亡调节分子；磷酸化可定位要降解的 CFLAR

Chk1

Akt1

人

S280

S280

AKRPRVtsGGVsEsP

15107605, 12062056

在 DNA 损伤期间调节 G2/M 转运的 DNA 损伤效应因子；磷酸化可通过防止 ATM/ATR 磷酸化来抑制功能

CK1-D

Akt1

大鼠

S370

S370

MERERKVsMRLHRGA

17594292

生物钟的激酶和核心组分；磷酸化可抑制激酶活性

CLK2

Akt1

人

S34, T127

S34, T127

HKRRRSRsWSSSSDR, RRRRRSRtFSRSSSQ

20682768

一种双重特异性丝氨酸/苏氨酸和酪氨酸激酶；磷酸化可在电离辐射后提高细胞存活率

Cot

Akt1

人

S400

S400

EDQPRCQsLDSALLE

12138205

致癌基因；磷酸化会诱导 NF-κB 依赖性转录

CREB

Akt1

大鼠

S133

S133

EILsRRPsYRkILND

9829964

可通过 cAMP 应答元件激活靶标基因的 bZIP 转录因子；经由磷酸化激活

CTNNB1

Akt1, Akt2

人

S552

S552

QDtQRRtsMGGtQQQ

17287208

Wnt 信号转导通路蛋白；磷酸化会导致胞核定位

CTNND2

Akt1

小鼠

T454

T457

tGTFRtstAPssPGV

17993462

在黏附分子调节中起作用的转录激活剂；磷酸化可促进与 p190RhoGEF 的结合以及形成树突状形态

Cx43

Akt1

大鼠

S369

S369

RPssRAssRAssRPR

18163231

间隙连接蛋白；磷酸化可实现 14-3-3 结合

Akt1, Akt3

大鼠

S373

S373

RAssRAssRPRPDDL

17008717, 18163231

DLC1

Akt1

大鼠

S330

S766

VTRTRSLsTCNKRVG

16338927

抑癌基因和胰岛素刺激的磷蛋白，可能在 Glut4 转位中起作用；磷酸化可抑制其 GAP 活性

DNAJC5

Akt1

大鼠

S10

S10

DQRQRsLsTSGESLY

16243840

胞外分泌；磷酸化可调节末期胞外分泌的动力

DNMT1

Akt1

人

S143

S143

RtPRRsksDGEAkPE

21151116

一种维持性甲基转移酶，可在复制期间将适当的甲基化模式转运至新合成的 DNA；磷酸化会增加 DNMT1 稳定性并防止甲基化

EDC3

Akt1, Akt2

人

S161

S161

sFRRRHNsWssSsRH

20051463

在删除 mRNA 5' cap 结构的过程中起作用；磷酸化会诱导 14-3-3 蛋白相互作用，并通过 mRNA 促进 ED3 介导的转录后调节

EDG-1

Akt1

人

T236

T236

RTRSRRLtFRKNISK

11583630

G 蛋白偶联受体；磷酸化可激活信号转导，进而促进细胞迁移

eIF4B

Akt1

小鼠

S422

S422

RERsRtGsEssQtGA

18836482

为mRNA 结合核糖体所必需；磷酸化可增强转录活性

ENaC-a

Akt1

大鼠

S621

S594

RFRSRYWsPGRGARG

21220922

一种介导钠重吸收，对阿米洛利敏感的上皮钠通道；磷酸化可特异地提高 ENaC活性

eNOS

Akt1

人

S615, S1177

S615, S1177

SYKIRFNsISCSDPL, TsRIRtQsFsLQERQ

12511559, 12446767, 10376603, 18622039, 12171920

可催化产生一氧化氮 (NO) 的酶；磷酸化会导致酶激活、NO 产生以及心血管稳态（血管扩张、血管重构、血管生成）

EphA2

Akt1

人

S897

S897

RVsIRLPstsGsEGV

19573808

受体酪氨酸激酶，可结合 GPI 锚定肝配蛋白 A 配体，进而调节细胞黏附、细胞迁移、轴突导向以及稳态；磷酸化可调节 EphA2 诱导的细胞迁移和侵袭

ER-a

Akt1, Akt2

人

S167

S167

GGRERLAsTNDKGSM

11139588, 16113102, 11507039

核受体和转录因子；磷酸化可激活受体并增加基因表达，进而导致乳腺和子宫细胞增殖

Akt1

人

S305

S305

IkRSkkNsLALSLtA

20101208

ER-b

Akt1

小鼠

S236

D236

VRRQRSAsEQVHCLN

17166829

核受体和转录因子；磷酸化可防止辅因子结合并降低活性

EZH2

Akt1

人

S21

S21

CWRKRVKsEYMRLRQ

16224021

甲基转移酶；磷酸化可降低 Lys27 的组蛋白 H3 甲基化并增加基因表达

ezrin

Akt2

人

T567

T567

QGRDKYKtLRQIRQG

15531580

质膜/细胞骨架连接蛋白；磷酸化可促进肌动蛋白结合和细胞骨架构建

FANCA

Akt1

人

S1149

S1149

CLRSRDPsLMVDFIL

11855836

参与 DNA 修复的 ATP 酶；磷酸化可通过 Akt 实现负调节

FLEG1

Akt1

人

S486

S486

GLEtRRLsLPSsKAK

17256767

在将特定组蛋白转运至着丝点的过程中起作用的一种伴侣蛋白；磷酸化可实现与 14-3-3 的结合

FLNC

Akt1, Akt2

人

S2233

S2233

LGRERLGsFGsItRQ

15461588

在肌细胞中起作用的肌细胞特异性细丝蛋白；磷酸化作用目前未知

FOXA2

Akt1

人

T156

T156

KTYRRSYtHAKPPYS

14500912

参与胚胎发育和分化的转录因子；磷酸化会排除细胞核并抑制 FoxA2 依赖性转录活性

FOXG1

Akt1

人

T279

T279

KLRRRSttsRAKLAF

17435750

参与脑发育的转录抑制因子；磷酸化可促进胞核输出

FOXO1A

Akt1

人

S256, S319, T24

S256, S319, T24

sPrRrAAsMDNNSkF, TFRPRtssNAsTIsG, LPRPRSCtWPLPRPE

15668399, 10358075, 11237865, 16076959, 11311120

参与细胞周期停滞、凋亡和葡萄糖代谢的转录因子；磷酸化会导致胞核输出并抑制活性

FOXO3A

Akt1

人

S253, T32

S253, T32

APRRRAVsMDNSNKY, QSRPRsCtWPLQRPE

10910908, 10995739, 10102273, 11154281

参与细胞周期停滞和凋亡的转录因子；磷酸化会导致胞核输出并抑制活性

FOXO4

Akt1

人

S197, S262, T32

S197, S262, T32

APRRRAAsMDSSSKL, TFRPRSssNASSVST, QSRPRsCtWPLPRPE

11313479, 11313479, 10217147, 16272144

参与细胞周期停滞、凋亡和胰岛素信号转导的转录因子；磷酸化会导致胞核输出并抑制活性

Gab2

Akt1

人

S159

S159

LLRERKSsAPSHsSQ

11782427

停靠/支架蛋白、原癌基因、RTK 信号转导介质；磷酸化会抑制活性

GABRB2

Akt1

大鼠

S434

S434

SRLRRRAsQLKITIP

12818177

介导脑部快速抑制性突触传递的受体；磷酸化可增强细胞表面上的受体数量

GAPDH

Akt2

人

T237

T237

GMAFRVPtANVSVVD

21979951

在糖酵解期间催化甘油醛-3-磷酸的磷酸化；磷酸化会减少核转位以及 GAPDH 诱导的凋亡

GATA1

Akt1

人

S310

S310

QTRNRKAsGkGkkkR

16107690

转录因子；磷酸化会增强活性并促进血细胞分化

GATA2

Akt1

人

S401

S401

QTRNRKMsNKSKKSK

15837948

转录因子；磷酸化会抑制活性，进而促进脂肪生成并减少炎症

girdin

Akt1

人

S1417

S1417

INRERQKsLtLTPTR

16139227

肌动蛋白结合蛋白；磷酸化可促进细胞迁移

GOLGA3

Akt1

小鼠

S174, S385

S174, S389

VKRHRERsSQPAtKM, EVRsRRDsICsSVSM

17888676

高尔基体自身抗原；磷酸化会减少凋亡

Grb10

Akt1

小鼠

S455

S428

NAPMRsVsENsLVAM

15722337

一种与许多受体酪氨酸激酶以及下游信号分子相互作用的衔接蛋白；磷酸化可实现与 14-3-3 的结合

GSK-3a

Akt1

人

S21

S21

SGRARtssFAEPGGG

11340086, 11563975, 11577096

磷酸化糖原合成酶并使之失活的丝氨酸/苏氨酸蛋白激酶；磷酸化会抑制活性

GSK-3b

Akt1

人

S9

S9

SGRPRttsFAESCKP

12900420, 15457186, 11563975, 11340086, 11577096, 8985174

磷酸化糖原合成酶并使之失活的丝氨酸/苏氨酸蛋白激酶；磷酸化会抑制活性

H2B

Akt1

人

S37

S37

RKRsRkEsysIyVyk

8985174

核小体的核心组分；磷酸化作用目前未知

H3

Akt1

小鼠

S10

S10

tKQTARksTGGkAPR

12529330

核小体的核心组分；磷酸化与有丝分裂和减数分裂期间的染色体凝聚有关

HMOX1

Akt1

人

S188

S188

LYRSRMNsLEMtPAV

15581622

参与应激反应的血红素氧合酶；磷酸化可调节结合亲和力

hnRNP A1

Akt1

人

S199

S199

sQrGrsGsGNFGGGr

18562319

在 mRNA 预包装进入 hnRNP 颗粒以及多聚腺苷酸 (A) mRNA 从细胞浆转运至胞核的过程中起作用；磷酸化可调节在周期素 D1 和 c-Myc IRES 活性中的作用

hnRNP E1

Akt1, Akt2

小鼠

S43

S43

VKRIREEsGARINIS

20154680

结合单链核酸；磷酸化会导致 BAT 成分结合中断以及 Dab2 和 ILEI mRNA 的转录激活

HSP27

Akt1

人

S82

S82

RALsRQLssGVSEIR

12740362

对应激和不良环境变化具有细胞抵抗性的热休克蛋白；磷酸化会改变三级结构，调节肌动蛋白聚合并进行重新组织

HTRA2

Akt1, Akt2

人

S212

S212

RVRVRLLsGDTYEAV

17311912

在凋亡期间释放的蛋白酶；磷酸化会抑制活性并减弱促凋亡作用

Huntingtin

Akt1

人

S421

S421

GGRsRsGsIVELIAG

12062094, 14725621, 15843398, 16452687

亨廷顿氏舞蹈病；Akt 磷酸化会抑制核聚合并提供神经保护

IKK-a

Akt1, Akt2

人

T23

T23

EMRERLGtGGFGNVC

18515365, 12048203, 10485710, 19609947

NF-kB 信号转导介质；磷酸化会激活 NF-κB 和免疫/应激反应

IP3R1

Akt1

大鼠

S2682

S2690

FPRMRAMsLVSSDSE

16332683

Ca2+ 释放和信号转导；磷酸化可能会通过Caspase 3 失活诱导凋亡抵抗性

IRAK1

Akt1

人

T100

T100

LRARDIItAWHPPAP

11976320

参与 Toll 信号转导的一种丝氨酸/苏氨酸特异性 IL-1 受体相关激酶；磷酸化会抑制 IRAK 介导的 NK-κB 激活

IRS1

Akt1

人

S629

S629

VPSGRKGsGDyMPMs

17640984

胰岛素受体信号转导介质；磷酸化会抑制相应功能

Akt1

大鼠

S522

S527

RFRKRTHsAGTSPTI

17579213

KHSRP

Akt1, Akt2

人

S193

S193

GLPERSVsLTGAPES

17177604

募集降解组织，激活 mRNA 转化，调节剪切；磷酸化会通过降解抑制 RNA 转化

Kv11.1 iso5

Akt1

人

T897

T897

SFRRRtDtDtEQPGE

18791070

电压门控钾通道的孔隙亚基，是心肌和内分泌细胞的节奏兴奋性所必需的；磷酸化会抑制通道

Lamin A/C

Akt1

大鼠

S301, S404

S301, S404

RSRGRASsHSSQSQG

18808171

核纤层的组分；磷酸化可调节核纤层的作用

LTB4R2

Akt1

人

T355

T355

GGRsREGtMELRTTP

22044535

参与趋化过程的一种低亲和力白三烯受体；磷酸化可调节趋化反应的激活

Mad1

Akt1

人

S145

S145

IERIRMDsIGSTVSS

18451027, 19526459,

纺锤体检查点的组分；磷酸化会导致泛素化和通过 26S 蛋白酶体通路降解

MDM2

Akt1

人

S166, S186, S188

S166, S186, S188

SsRRRAIsEtEENsD, RQRKRHKsDsIsLsF, RKRHKsDsIsLsFDE

11715018, 15169778, 11504915, 11850850, 11923280, 15527798, 11960368

参与 p53 降解的泛素连接酶；磷酸化会导致胞核转位以及 p53 抑制

MDM4

Akt1

人

S367

S367

PDCRRtIsAPVVRPK

18356162

参与 p53 降解和凋亡的环指结构域蛋白；磷酸化可稳定 MDM4 和 MDM2

METTL1

Akt1

人

S27

S27

yYRQrAHsNPMADHT

15861136

催化 tRNA 中 m7G46 的形成；磷酸化会导致失活

MKK4

Akt1

人

S80

S80

IERLRtHsIEsSGKL

15911620, 11707464

在应激/炎症中起作用的 JNK/SAPK 通路的信号转导介质；磷酸化会抑制活性

MLK3

Akt1

人

S674

S674

PGRERGEsPTtPPTP

12458207

JNK 介导的神经元细胞死亡；磷酸化会抑制活性

MST1

Akt1

人

T120

T120

IIRLRNktLTEDEIA

19940129

促凋亡激酶；磷酸化会抑制激酶活性和核转位，进而抑制促凋亡信号转导

MST2

Akt1

人

T117, T384

T117, T384

IIRLRNktLIEDEIA, GTMKRNAtsPQVQRP

20231902, 20086174

MAPK 通路的上游激活剂，可调节凋亡、形态形成及细胞骨架重排；磷酸化会抑制促凋亡活性

mTOR

Akt1

人

T2446, S2448

T2446, S2448

RsRtRtDsysAGQsV

15208671, 10910062, 10567225

蛋白质合成和细胞生长；磷酸化会增强活性

MYO5A

Akt2

小鼠

S1650

S1652

GLRKRtssIADEGty

17515613

肌动蛋白马达蛋白，在细胞浆囊泡转运和锚定过程中起作用；磷酸化会促进胰岛素介导的 Glut4 囊泡转位

Myt1

Akt1

海星

S75

S83

ESRPRAVsFRQSEPS

11802161

Wee1 家族成员和细胞周期调节分子；磷酸化会下调 Myt1 并开始 M 期

NDRG2

Akt1

人

S332, T348

S332, T348

LsRsRtAsLtsAAsV, GNRsRsRtLsQssEs

15461589

胰岛素刺激的磷蛋白；磷酸化可促进胰岛素信号转导

NFAT90

Akt1

人

S647

S647

rGrGRGGsIRGRGRG

18097023, 20870937

翻译抑制蛋白；磷酸化为核输出所必需

NHE1

Akt1

人

S648, S703, S796

S648, S703, S796

KTRQRLRsyNRHTLV, MsRARIGsDPLAyEP, QRIQRCLsDPGPHPE

18757828, 20026127

参与 pH 调节和信号转导的钠/氢交换泵；磷酸化会抑制活性

NMDAR2C

Akt1

小鼠

S1084

S1081

GPRPRHAsLPSSVAE

19477150

谷氨酸受体通道亚基；磷酸化可促进与 14-3-3ε 的结合，并导致小脑 NMDA 受体的表面表达升高

Akt1

大鼠

S1083

S1081

GPRPRHAsLPSSVAE

19477150

NuaK1

Akt1

人

S600

S600

PARQRIRsCVSAENF

15060171, 12409306

在葡萄糖饥饿的条件下被激活的 AMPK 家族成员，可介导细胞存活；磷酸化可增强激酶活性

Nur77

Akt1

人

S351

S351

GRRGRLPsKPKQPPD

16434970, 11274386

调节 T 细胞凋亡的核受体和转录因子；磷酸化会抑制转录活性

p21 Cip1

Akt1

人

S146, T145

S146, T145

GRkRRQtsMTDFYHs, QGRkRRQtsMTDFYH

17855660, 11231573, 11756412, 15173090, 11463845, 116982699

调节细胞周期和细胞存活；磷酸化会增强蛋白质稳定性

p27Kip1

Akt1

人

S10, T157, T198

S10, T157, T198

NVRVsNGsPsLErMD, GIRkrPAtDDSSTQN, PGLRRRQt_______

18710949, 12042314, 12244302

一种可强化 G1 细胞周期限制点的周期素依赖性激酶抑制剂；磷酸化可促进 14-3-3 的结合及细胞浆定位

p300

Akt1

人

S1834

S1834

MLRRRMAsMQRTGVV

16024795, 11116148

转录共激活剂；磷酸化可激活或抑制转录活性，具体取决于细胞类型和生理刺激

p47phox

Akt1

人

S304, S328

S304, S328

GAPPRRssIRNAHSI, QDAYRRNsVRFLQQR

12734380

吞噬性 NADPH 氧化酶多蛋白酶的一种组分，可在病原菌侵入时起催化作用，将氧还原为超氧化物；磷酸化可调节 p47hox 呼吸爆发行为

PAK1

Akt1

小鼠

S21

S21

APPMRNTsTMIGAGS

14585966

一种 p21 激活激酶，参与细胞骨架重组、MAPK 信号转导、凋亡信号转导、吞噬性 NADPH 氧化酶的控制以及生长因子诱导的神经突增生；Ser21 位点的磷酸化可调节与接头蛋白 Nck 的结合

palladin

Akt1

人

S1118

S1118

VRRPRsRsRDsGDEN

20471940

肌动蛋白纤维束蛋白；磷酸化可促进 F-肌动蛋白结合并抑制细胞迁移

PAR-4

Akt1

大鼠

S249

N257

SRHNRDTsAPANFAS

16209943

一种促凋亡因子，可激活 Fas-FADD-Caspase-8 通路并抑制 NF-κB 促活通路；磷酸化可防止核转位并促进细胞存活

PDCD4

Akt1

人

S67, S457

S67, S457

kRRLRKNssRDsGRG, RGRKRFVsEGDGGRL

16357133

在凋亡期间被强烈诱导的抑癌基因蛋白；磷酸化会抑制抑癌基因的作用

PDE3A

Akt1

小鼠

S290, S291, S292

S290, S291, S292

GWKRRRRsssVVAGE, WKRRRRsssVVAGEM, KRRRRsssVVAGEMS

17124499

调节 cAMP 和 cGMP 水平、胰岛素依赖性卵母细胞的成熟；磷酸化可增强活性

PDE3B

Akt1

小鼠

S273

S295

VIRPRRRssCVsLGE

10454575

调节 cAMP 和 cGMP 水平，可被胰岛素激活，进而调节脂类分解；磷酸化可增强活性

PEA-15

Akt1

人

S116

S116

KDIIRQPsEEEIIKL

12808093

一种被证明可调节细胞生长、死亡以及葡萄糖利用的磷蛋白；磷酸化可介导与 FADD 或 Erk 的结合，进而调节 Erk 和凋亡信号转导通路

peripherin

Akt1

小鼠

S66

S59

SSSARLGsFRAPRAG

17569669

神经元中间纤丝蛋白；磷酸化可促进运动神经再生

PFKFB2

Akt1

人

S466, S483

S466, S483

PVRMRRNsFtPLSSS, IRRPRNysVGSRPLK

12853467

糖酵解酶，胰岛素介导的葡萄糖代谢；磷酸化可增强活性

PFKFB3

Akt1

人

S461

S461

NPLMRRNsVtPLAsP

15896703

果糖 2,6 -二磷酸的合成和降解；磷酸化会降低抑制敏感性

PGC-1 a

Akt1, Akt2

小鼠

S570

S571

RMRSRsRsFsRHRSC

17554339

调节糖异生和脂肪酸氧化；磷酸化会抑制功能

PIP5K

Akt1

人

S307

S307

PARNRsAsItNLsLD

15546921

参与膜转运的一种蛋白/脂质激酶；在胰岛素的刺激下被磷酸化

Akt1

小鼠

S105

S105

EELHRRSsVLENTLP

20513353

PLB

Akt1

大鼠

S16

S16

RSAIRRAstIEMPQQ

18838385

肌质网的一种主要磷蛋白钙调节组分；磷酸化会导致抑制作用的释放并通过肌质网增加钙摄取

PLCG1

Akt1

人

S1248

S1248

HGRAREGsFEsRyQQ

16525023

催化 PI 4,5二磷酸生成 IP3 和 DAG，增加胞内 Ca2+ 水平；磷酸化会增强活性并增强 EGF 刺激的细胞运动性

PPP1CA

Akt1

人

T320

T320

NPGGRPItPPRNSAK

14633703

参与细胞周期调节的一种丝氨酸/苏氨酸磷酸酶；磷酸化会抑制活性

PRAS40

Akt1

人

T246

T246

LPRPRLNtsDFQKLK

12524439, 17277771, 18372248

结合并抑制 mTOR；磷酸化会导致 14-3-3 结合/抑制，并增强蛋白质合成

PRPF19

Akt1

人

T193

T193

ERKKRGKtVPEELVK

20629186

在 DNA 双链断裂修复中起作用的一种剪接体成员；磷酸化可实现 14-3-3 结合

PRPK

Akt1

人

S250

S250

RLRGRKRsMVG____

17712528

p53 结合蛋白和激酶；磷酸化会导致激活及 p53 磷酸化

PTP1B

Akt1

人

S50

S50

RNRyRDVsPFDHsRI

11579209

对胰岛素受体去磷酸化的蛋白酪氨酸磷酸酶；磷酸化会抑制活性

QIK

Akt2

小鼠

S358

S358

DGRQRRPstIAEQTV

17805301

AMPK 相关蛋白；磷酸化会导致激酶激活并促进 TORC2 的泛素化/降解

Rac1

Akt1

人

S71

S71

yDRLRPLsYPQTDVF

10617634

Rho-GTP 酶，肌动蛋白细胞骨架组织；磷酸化会抑制 GTP 结合活性

Raf1

Akt1

小鼠

S259

S259

SQRQRStsTPNVHMV

12087097, 12087097

Erk1/2 通路的信号转导介质；磷酸化会抑制活性

Akt1

大鼠

S259

S259

SQRQRSTsTPNVHMV

11443134

RANBP3

Akt1

人

S126

S126

VKRERtssLtQFPPs

18280241

在核转运中起作用的 RAN 结合蛋白3；磷酸化可介导 Ran 结合并调节核转运

RARA

Akt1

人

S96

S96

FVCQDKSsGYHYGVS

16417524

作为一种基因表达直接调节分子的维甲酸核受体；DNA 结合域的磷酸化会抑制 RARA 活性

RGC32

Akt1

人

S65

S65

ERMKRRSsAsVSDSS

19162005

对 DNA 损伤产生响应的一种细胞周期特异性激酶调节分子；磷酸化会激活和调节生长因子。

RNF11

Akt1

人

T135

T135

DWLMRSFtCPSCMEP

16123141

调节瞬时炎症信号转导的一种泛素编辑复合体成员；磷酸化可实现 14-3-3 结合

Ron

Akt1

人

S1394

S1394

VRRPRPLsEPPRPT_

12919677, 14505491

巨噬细胞刺激蛋白 (MSP)、细胞黏附、增殖和迁移的受体酪氨酸激酶；磷酸化可导致14-3-3 结合

RPS3

Akt1

人

T70

T70

GrrIrELtAVVQkRF

20605787

40S 核糖体亚基的一个成员，同样可诱导神经元凋亡并作为一种核酸内切酶；磷酸化会抑制促凋亡功能，增加核输入/聚集，并增强 DNA 修复

S6

Akt1

小鼠

S236

S236

AKRRRLssLRAstsK

12151408

S6 核糖体蛋白；磷酸化会激活蛋白并促进蛋白质合成

Akt1, Akt2

大鼠

S235, S236

S235, S236

IAKRRRLssLRAsts, AKRRRLssLRAstsK

15358595

SFRS5

Akt2

大鼠

S86

S86

GRGRGRYsDRFSSRR

15684423

参与组成型和选择性剪切的一种剪接体；磷酸化会激活选择性剪切外显子加入

SH3BP4

Akt1

小鼠

S245

S246

FRSKRSysLsELsVL

19122209

通过内吞控制转运受体的选择性内化；磷酸化可促进在质膜的 14-3-3 结合

SH3RF1

Akt1, Akt2

人

S304

S304

KNTKKRHsFtsLTMA

17535800

结合激活的 Rac 并通过 JNK 激活促进凋亡的支架蛋白；磷酸化可减弱结合 Rac 的能力，进而促进凋亡

SKI

Akt1

人

T458

T458

QPRKRKLtVDTPGAP

19875456

通过结合 Smads 的 TGF-b 信号转导的负调节分子；磷酸化会导致不稳定性，并减少 Smad7 表达的 SKI 介导的抑制作用

SOX2

Akt1

小鼠

T118

T116

kYRPRRktkTLMkKD

20945330

一种早期胚胎形成和胚胎干细胞多能性所需的转录因子；磷酸化可稳定 SOX2，进而增强转录活性

SRPK2

Akt1

人

T492

T492

PSHDRSRtVsAsstG

19592491

定位剪接因子丝氨酸/精氨酸家族的一种蛋白激酶；磷酸化会导致核转位以及靶标的上调，进而调节细胞周期进程和凋亡

SSB

Akt1

小鼠

T301

T302

LLRNKKVtWKVLEGH

18836485

RNA 结合蛋白，在 RNA 聚合酶 III 转录的加工中起作用；磷酸化可促进输出至细胞浆，以结合多核糖体并调节特定 mRNA 集的表达

STXBP4

Akt2

小鼠

S99

S99

RAKLRsEsPWEIAFI

15753124

抑制胞内囊泡的形成和转位；STXBP4 胰岛素刺激的磷酸化会释放抑制作用

SYTL1

Akt1

人

S241

S241

RMLSSSSsVSSLNSS

15998322

参与颗粒胞吐的一个分泌因子家族成员；磷酸化可调节 SYTL1 亚核定位

TAL1

Akt1

人

T90

T90

EARHRVPttELCRPP

15930267, 19406989

转录因子；磷酸化可抑制转录抑制因子活性并调节胞内定位

TBC1D1

Akt1

人

T596

T596

AFRRRANtLsHFPIE

17995453

参与胰岛素刺激 Glut4 转运的 Rab GTP 酶激活蛋白；磷酸化可促进葡萄糖转运

TERT

Akt1

人

S227, S824

S227, S824

GARRRGGsASRSLPL, AVRIRGKsYVQCQGI

10224060

端粒酶逆转录酶，可维持染色体长度；磷酸化会增强端粒酶活性

THOC4

Akt1

人

S34, T219

S34, T219

RGRGRAGsQGGrGGG, GGGtrRGtRGGARGR

18562279

作为转录因子二聚化伴侣蛋白的 RNA 结合和输出蛋白；磷酸化可调节 THOC4 亚核定位并激活 mRNA 输出和细胞增殖

TOPBP1

Akt1

人

S1159

S1159

EERARLAsNLQWPSC

19477925

诱导 ATR 激酶活性的大幅增强；磷酸化会防止 DNA 损伤后 ATR 与 TopBP1 的关系更加紧密

TRF1

Akt1

人

T273

T273

SKRTRTItSQDKPSG

19160102

控制端粒结构；磷酸化会缩短端粒长度

TSC2

Akt1

人

S939, S981, T1462

S939, S981, T1462

sFRARstsLNERPKs, AFRCRSIsVSEHVVR, GLRPRGytIsDSAPs

15342917, 12150915, 16636147

抑制 mTOR 的抑癌基因；磷酸化可抑制功能并实现蛋白质合成

Akt1

大鼠

S1130, S1132

S1130, S1132

GARDRVRsMsGGHGL, RDRVRsMsGGHGLRV

12172553

TTC3

Akt1

人

S378

S378

AYTPRsLsAPIFTTS

20059950

Akt 的 E3 连接酶；磷酸化可促进 TTC3 功能，如泛素化和降解 Akt 的能力

TWIST1

Akt1

人

S42, S123

S42, S123

GGRKRRSsRRSAGGG, RERQRTQsLNEAFAA

20400976

一种调节性碱性螺旋-环-螺旋抗凋亡转录因子；磷酸化可激活 TWIST1，进而抑制 p53 并促进细胞存活

USP8

Akt1

小鼠

T907

T945

TCRRRSRtFEAFMYL

17210635

在生长因子受体转运和降解中起作用的去泛素化酶；磷酸化可增加蛋白质稳定性

VCP

Akt1

人

S352, S746, S748

S352, S746, S748

AAtNRPNsIDPALRR, AMRFARRsVsDNDIR, RFARRsVsDNDIRky

16551632, 16027165

ATP 酶和分子伴侣；磷酸化会损坏促凋亡作用并促进细胞存活

Vimentin

Akt1

人

S39

S39

ttsTrtysLGsALRP

20856200

一种细胞骨架中间纤丝蛋白；磷酸化可通过防止蛋白水解作用诱导细胞运动和侵袭

Wee1

Akt1

人

S642

S642

KKMNRsVsLTIy___

15964826

通过 cdc2 激酶的磷酸化抑制来抑制细胞周期进程的一种蛋白激酶；磷酸化可促进 Wee1 定位从胞核变为细胞浆，且与 G2/M 停滞有关

WNK1

Akt1

人

T60

T60

EYRRRRHtMDKDSRG

14611643, 16081417

调节离子通道；WNK1 磷酸化会激活 SGK1 并调节钠离子转运

XIAP

Akt1, Akt2

人

S87

S87

VGRHRKVsPNCRFIN

14645242, 17537996

凋亡的抑制剂；磷酸化可防止泛素化/降解，并使细胞存活率升高

YAP1

Akt1

人

S127

S127

PQHVRAHssPAsLQL

12535517

PEBP2 和其他转录因子的一种转录共激活剂；磷酸化会抑制 p73 介导的凋亡

YB-1

Akt1

人

S102

S102

NPRKyLRsVGDGEtV

22417301

在 mRNA 稳定性和表达方面起作用的一种转录/翻译因子；磷酸化会诱导胞核激活和转位

zyxin

Akt1

人

S142

S142

PQPREKVssIDLEId

17572661

在细胞浆和胞核之间运动的一种局灶黏附分子；磷酸化可促进与腺泡和抗凋亡活性之间的联系

创建于 2008 年 10 月

修订时间 2015 年 6 月

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AKT 丝氨酸/苏氨酸激酶 1（AKT1）基因 | MCE

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Gene

AKT1 - AKT serine/threonine kinase 1 Gene

AKT1 - AKT serine/threonine kinase 1 Gene

基因

蛋白

疾病

相关产品

直系同源

中文名称：AKT 丝氨酸/苏氨酸激酶 1

种属: Homo sapiens

同用名: AKT; PKB; RAC; PRKBA; PKB-ALPHA; RAC-ALPHA

基因 ID: 207

|

基因类型: protein coding

关于 AKT1

Cytogenetic location: 14q32.33

Genomic coordinates (GRCh38): 14:104,769,349-104,795,748 (from NCBI)

This gene has 22 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 132 phenotypes. Ubiquitous expression in prostate (RPKM 26.1), lung (RPKM 25.1) and 25 other tissues.

功能概要

该基因编码人类 Akt 丝氨酸-苏氨酸蛋白激酶家族的三个成员之一，通常称为蛋白激酶 B α、β 和γ。这些高度相似的 Akt 蛋白都有一个 N 端 pleckstrin 同源结构域、一个丝氨酸/苏氨酸特异性激酶结构域和一个 C 端调节结构域。这些蛋白质被磷酸肌醇 3-激酶 (PI3K) 磷酸化。 Akt/PI3K 是许多信号通路的关键组成部分，这些信号通路涉及膜结合配体的结合，例如受体酪氨酸激酶、G 蛋白偶联受体和整合素连接激酶。因此，这些 Akt 蛋白调节多种细胞功能，包括正常细胞和恶性细胞中的细胞增殖、存活、代谢和血管生成。磷脂酰肌醇 4,5-二磷酸 (PIP2) 被 PI3K 磷酸化后，Akt 蛋白被磷脂酰肌醇 3,4,5-三磷酸 (PIP3) 募集到细胞膜上。苏氨酸残基 308 和丝氨酸残基 473 的后续磷酸化是完全激活该基因编码的 Akt1 蛋白所必需的。其他残基的磷酸化也会发生，例如，响应胰岛素生长因子-1 和表皮生长因子。蛋白磷酸酶通过使 Akt 或 PIP3 去磷酸化而充当 Akt 蛋白的负调节剂。 PI3K/Akt 信号通路对肿瘤细胞存活至关重要。存活因子可以通过激活 Akt1 以转录非依赖性方式抑制细胞凋亡，然后磷酸化和灭活细胞凋亡机制的组分。 Akt 蛋白还参与哺乳动物雷帕霉素靶标 (mTOR) 信号通路，该通路控制真核翻译起始因子 4F (eIF4E) 复合物的组装，并且除了响应来自生长因子和细胞因子的细胞外信号外，该通路在许多癌症。该基因的突变与多种类型的癌症和组织过度生长有关，包括变形杆菌综合征和考登综合征 6，以及乳腺癌、结直肠癌和卵巢癌。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2020 年 7 月]

This gene encodes one of the three members of the human Akt serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar Akt proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). Akt/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as Receptor Tyrosine Kinases, G-protein coupled receptors, and integrin-linked kinase. These Akt proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. Akt proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the Akt1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to Insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of Akt proteins by dephosphorylating Akt or PIP3. The PI3K/Akt signalling pathway is crucial for tumor cell survival. Survival factors can suppress Apoptosis in a transcription-independent manner by activating Akt1 which then phosphorylates and inactivates components of the apoptotic machinery. Akt proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of Cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]

AKT1 基因产物(14)

mRNA

Protein

Name

NM_001014432.2

NP_001014432.1

RAC-alpha serine/threonine-protein kinase

NM_005163.2

NP_005154.2

RAC-alpha serine/threonine-protein kinase

XM_047431073.1

XP_047287029.1

RAC-alpha serine/threonine-protein kinase isoform X1

XM_047431072.1

XP_047287028.1

RAC-alpha serine/threonine-protein kinase isoform X1

XM_047431074.1

XP_047287030.1

RAC-alpha serine/threonine-protein kinase isoform X1

XM_047431075.1

XP_047287031.1

RAC-alpha serine/threonine-protein kinase isoform X1

XM_047431070.1

XP_047287026.1

RAC-alpha serine/threonine-protein kinase isoform X1

XM_047431071.1

XP_047287027.1

RAC-alpha serine/threonine-protein kinase isoform X1

NM_001382432.1

NP_001369361.1

RAC-alpha serine/threonine-protein kinase

NM_001014431.2

NP_001014431.1

RAC-alpha serine/threonine-protein kinase

NM_001382431.1

NP_001369360.1

RAC-alpha serine/threonine-protein kinase

NM_001382433.1

NP_001369362.1

RAC-alpha serine/threonine-protein kinase

XM_047431069.1

XP_047287025.1

RAC-alpha serine/threonine-protein kinase isoform X1

NM_001382430.1

NP_001369359.1

RAC-alpha serine/threonine-protein kinase

AKT1 蛋白结构

PH

PH: PH domain (6 - 106)

Pkinase

Pkinase: Protein kinase domain (151 - 408)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (428 - 475)

0

100

200

300

400

480 a.a.

蛋白主名

其他名称

RAC-alpha serine/threonine-protein kinase

AKT1m

PKB alpha

RAC-PK-alpha

protein kinase B alpha

proto-oncogene c-Akt

rac protein kinase alpha

serine-threonine protein kinase

v-akt murine thymoma viral oncogene homolog 1

v-akt murine thymoma viral oncogene-like protein 1

重组 AKT1 蛋白

目录号

产品名

蛋白编号

纯度

HY-P74421

AKT1 Protein, Human (sf9, His)

P31749 (M1-A480)

≥95%

关联疾病

疾病名称

别名

Localized Osteosarcoma

Localised Osteogenic Sarcoma

Localised Osteosarcoma

Localized Osteogenic Sarcoma

Insulin-Like Growth Factor I

Insulin-Like Growth Factor I Deficiency

IGF1 DEFICIENCY

Insulin-Like Growth Factor I, Resistance To

Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor I Resistance

IGF1RES

Igf-I Resistance

Growth Retardation With Sensorineural Deafness And Mental Retardation

Somatomedin, End-Organ Insensitivity To

Somatomedin-C

Somatomedin-C, Resistance To

Insulin-Like Growth Factor 1 Resistance To

Igf-1 Resistance

Somatomedin End-Organ Insensitivity To

Somatomedin-C Resistance To

Growth Delay-Deafness-Intellectual Disability Syndrome

Growth Delay-Hearing Loss-Intellectual Disability Syndrome

Igf-1 Deficiency

Primary Insulin-Like Growth Factor Deficiency

Resistance To Igf-1

Insulin-Like Growth Factor 1 Resistance

End-Organ Insensitivity To Somatomedin

Igf1 Resistance

Resistance To Insulin-Like Growth Factor I

Resistance To Somatomedin-C

Insulin-Like Growth Factor 1, Resistance To

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability

Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Diabetic Encephalopathy

Gallbladder Disease

Gallbladder Diseases

Gall Bladder

Gall Bladder Diseases

Abnormal Gallbladder Function

Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma

Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma

Intrahepatic Bile Duct Carcinoma

Peripheral Cholangiocarcinoma

Peripheral Intrahepatic Cholangiocarcinoma

Adenocarcinoma Of Intra-Hepatic Bile Ducts

Cholangiocarcinoma, Unspecified Site

Cholangiocarcinoma Of Liver

Toxic Encephalopathy

Neurotoxicity

Neurotoxicity Syndromes

Neurotoxicity Syndrome

Encephalopathy, Toxic

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Squamous Cell Skin Cancer

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Uveal Disease

Uveal Diseases

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Tongue Carcinoma

Tongue Cancer

Malignant Neoplasm Of Tongue

Tongue Neoplasms

Tongue Neoplasm

Brain Cancer

Malignant Neoplasm Of Brain

Adult Brain Tumor

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary

Hyperostosis

Hypertrophy Of Bone

Bone Hypertrophy

Bone Thickening

Periosteum Thickening

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma

Adrenal Cortex Carcinoma

Carcinoma Of The Adrenal Cortex

Acc

Adrenocortical Cancer

Carcinoma Adrenocortical

Leukocyte Disease

Leukocyte Disorders

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Tumor Of Meninges

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Ocular Hypertension

Hypertension, Ocular

Intraocular Pressure Increase

Oh - [Ocular Hypertension]

Oht - [Ocular Hypertension]

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx

Hyperinsulinism

Hyperinsulinemia

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis

Nash

Nash - [Non-Alcoholic Steatohepatitis]

Non-Alcoholic Steatohepatosis

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Cowden Syndrome 6

CWS6

Cowden Syndrome, Type 6

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri

Colon Adenoma

Adenomatous Polyp Of Colon

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Serous Cystadenocarcinoma

Serous Adenocarcinoma

Cystadenocarcinoma, Serous

Serous Carcinoma

Cystadenocarcinoma Serous

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Female Reproductive Endometrioid Cancer

Endometrioid Tumor

Endometrioid Neoplasm

Female Reproductive Endometrioid Neoplasm

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Intestinal Benign Neoplasm

Intestinal Neoplasms

Intestinal Tumors

Intestine Growth

Neoplasm Of Intestinal Tract

Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Acquired Metabolic Disease

Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina

Brain Glioblastoma Multiforme

Brain Glioblastoma

Glioblastoma Multiforme Of Brain

Glioblastoma Nos

Cardiovascular Organ Benign Neoplasm

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity

Retrolental Fibroplasia

EVR1

Criswick-Schepens Syndrome

Rop

Exudative Vitreoretinopathy, Familial, Autosomal Dominant

Fevr, Autosomal Dominant

Premature Retinopathy

Vitreoretinopathy, Exudative 1

Autosomal Dominant Familial Exudative Vitreoretinopathy

Fevr

Vitreoretinopathy, Exudative, Type 1

Retinopathy Of Prematurity Nos

Rlf- [Retrolental Fibroplasia]

Rop - [Retinopathy Of Prematurity]

Terry Syndrome

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Estrogen-Receptor Positive Breast Cancer

Exanthem

Exanthema

Rash

Rashes

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Estrogen-Receptor Negative Breast Cancer

Bile Duct Disease

Bile Duct Diseases

Bile Duct Disorder

Disorder Of Bile Duct

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site

Anus Disease

Anal Fissure

Ulcer Of Anus

Anus Diseases

Anal Disease

Anal Fissure And Fistula

Anal Ulcer

Fissure In Ano

Nontraumatic Tear Of Anus

Solitary Anal Ulcer

Abnormality Of The Anus

Anal Disorders

Ulcer Of Anus And Rectum

Solitary Ulcer Of Anus

Stercoral Ulcer Of Anus

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Human Papillomavirus Infectious Disease

Hpv

Papillomavirus Infections

Human Papilloma Virus Infection

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung

Squamous Cell Lung Carcinoma

Epidermoid Cell Carcinoma Of The Lung

Squamous Cell Lung Cancer

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Hyperglycemia

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Thymoma

Primary Thymic Epithelial Neoplasm

Primary Thymic Epithelial Tumor

Thymus Neoplasms

Retinal Vascular Disease

Retinal Vascular

Retina Circulation Disorder

Retinal Vascular Disorder

Small Cell Cancer Of The Lung

Small Cell Lung Cancer

Small Cell Lung Carcinoma

Sclc

Small-Cell Cancer Of Lung

Lung Small Cell Carcinoma

Sclc1

Sccl

Cancer, Lung, Small Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell

Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Breast Lobular Carcinoma

Cancer, Breast, Lobular

Lobular Breast Carcinoma

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Autonomic Nervous System Neoplasm

Tumor Of Autonomic Nervous System

Rhabdomyosarcoma

Neutropenia

Leukopenia

Benign Ependymoma

Ependymoma

Epithelial Ependymoma

Who Grade Ii Ependymal Tumor

Myxopapillary Ependymoma

Aging

Lung Carcinoma In Situ

Muscle Cancer

Myosarcoma

Malignant Neoplasm Of Muscle

Malignant Tumor Of Muscle

Malignant Tumor Of The Muscle

Muscle Neoplasms

Myomatous Neoplasm

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Inherited Metabolic Disorder

Inborn Errors Of Metabolism

Inborn Metabolism Disorder

Metabolic Hereditary Disorder

Inborn Error Of Metabolism

Inborn Metabolic Disorder

Metabolism, Inborn Errors

Lung Oat Cell Carcinoma

Oat Cell Carcinoma

Carcinoma Oat Cell

Carcinoma, Small Cell

Subependymal Giant Cell Astrocytoma

Sega

Astrocytoma Subependymal Giant Cell

Subependymal Giant-Cell Astrocytoma

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Proteus Syndrome

Proteus Syndrome, Somatic

Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome

Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly

Wiedemann'S Syndrome

Hemihypertrophy And Macrocephaly

Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly

Ps

PROTEUSS

Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Malignant Exocrine Pancreas Neoplasm

Malignant Neoplasm Of The Exocrine Pancreas

Malignant Tumor Of Exocrine Pancreas

Malignant Tumour Of Exocrine Pancreas

Integumentary System Disease

Thymus Cancer

Thymic Tumor

Thymus Neoplasm

Thymus Neoplasms

Malignant Neoplasm Of Thymus

Neoplasm Of Thymus

Thymic Neoplasm

Thymic Neoplasms

Thymoma, Familial

Thymic Carcinoma

Thymoma, Type C

Cancer Of Thymus

Malignant Tumour Of Thymus

Primary Malignant Neoplasm Of Thymus

Thymic Glandular Cancer

Thymus Gland Cancer

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Skin Papilloma

Cutaneous Papilloma

Papilloma Of Skin

Papilloma Skin

Brain Glioma

Lower Grade Glioma

Intracranial Glioma

Glioma Nos

Immunodeficiency 14

Activated Pi3k-Delta Syndrome

Apds

Pasli Disease

Imd14

Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation

P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency

Uterine Benign Neoplasm

Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm

Infratentorial Cancer

Infratentorial Neoplasms

Brain Neoplasm, Infratentorial

Malignant Infratentorial Tumors

Tongue Disease

Abnormality Of The Tongue

Tongue Diseases

Tongue Disorders

Disorder Of Tongue

Glossopathy

Unspecified Condition Of The Tongue

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm

Neoplasm Of Mature B-Cells

Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos

Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis

Hemangioma

Hemangiomas

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Pancreatic Adenocarcinoma

Adenocarcinoma Of Pancreas

Adenocarcinoma Of The Pancreas

Pancreas Adenocarcinoma

Malignant Exocrine Neoplasm

Primary Pancreatic Adenocarcinoma

Adenocarcinoma Of Islet Cell Of Pancreas

Islet Cell Adenocarcinoma Of Unspecified Site

Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Reproductive Organ Benign Neoplasm

Cell Type Benign Neoplasm

Ovary Adenocarcinoma

Ovarian Adenocarcinoma

Adenocarcinoma Of The Ovary

Ovarian Adenoacanthoma

Adenocarcinoma Of Ovary

Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders

High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder

Pre-Malignant Neoplasm

Pfeiffer Syndrome

Infectious Mononucleosis

Acs5

Craniofacial-Skeletal-Dermatologic Dysplasia

Acs V

Noack Syndrome

Gammaherpesviral Mononucleosis

Acrocephalosyndactyly Type 5

Pfeiffer Syndrome Type 3

Acrocephalosyndactyly, Type V

Glandular Fever

Pfeiffer Type Acrocephalosyndactyly

Pfeiffer Syndrome Type 2

Acrocephalosyndactylia Type V

Filatov'S Disease

Monocytic Angina

Mononucleosis

Pfeiffer'S Disease

Acsv

Acrocephalosyndactyly, Type 5

Craniofacial-Skeletal-Dermatologic Syndrome

Pfeiffer Syndrome Type 1

Classic Pfeiffer Syndrome

PS

Pfeiffer Syndrome Variant

Dysplasia, Craniofacial-Skeletal-Dermatologic

Pfeiffer

Kissing Disease

Infectious Adenitis

Pfeiffer Disease

Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Leptin

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Teeth Hard Tissue Disease

Neurilemmoma

Schwannoma

Benign Schwannoma

Neurilemoma

Peripheral Fibroblastoma

Psammomatous Schwannoma

Neurolemmoma

Schwannomas

Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]

Childhood Osteosarcoma

Pediatric Osteosarcoma

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Peripheral Nervous System Neoplasm

Nerve Sheath Neoplasm

Peripheral Nervous System Neoplasms

Neoplasm Of Peripheral Nerve

Tumor Of Pns

Nerve Sheath Neoplasms

Nerve Sheath Tumors

Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]

Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders

Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Chordoma

CHDM

Notochordoma

Notochordal Sarcoma

Chordoma, Susceptibility To

Chordocarcinoma

Chordoepithelioma

Ovarian Serous Cystadenocarcinoma

Serous Cystadenoma

Cystadenoma Serous

Cystadenoma, Serous

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma

Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos

Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Acoustic Neurinoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Congenital Megacolon

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

Hirschsprung'S Disease

Congenital Intestinal Aganglionosis

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Skin Melanoma

Cutaneous Melanoma

Malignant Ear Melanoma

Malignant Lip Melanoma

Malignant Lower Limb Melanoma

Malignant Melanoma Of Ear And/Or External Auricular Canal

Malignant Melanoma Of Skin Of Lower Limb

Malignant Melanoma Of Skin Of Trunk Except Scrotum

Malignant Melanoma Of Skin Of Upper Limb

Malignant Neck Melanoma

Malignant Scalp Melanoma

Malignant Trunk Melanoma

Malignant Upper Limb Melanoma

Melanoma, Cutaneous Malignant

Melanoma

Malignant Melanoma Of Skin

Melanoma Nos

Malignant Mole, Meaning Melanoma Of Unspecified Site

Melanoma Of Unspecified Site

Cutaneous Malignant Melanoma

Mm - [Malignant Melanoma]

Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma

Cerebral Artery Occlusion

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Breast Carcinoma In Situ

Carcinoma In Situ Of Breast

Non-Infiltrating Carcinoma Of Breast

Breast Cancer In Situ

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Papilloma

Papillomatosis

Colitis

Autosomal Genetic Disease

Autosomal Hereditary Disorder

Ovarian Cystadenocarcinoma

Cystadenocarcinoma Of Ovary

Cystadenocarcinoma Of The Ovary

Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma

Biliary Tract Disease

Biliary Tract Diseases

Biliary Tract Abnormality

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 5

MVCD5

Retinopathy, Diabetic

Diabetic Nephropathy

Retinopathy, Diabetic, Susceptibility To

Retinal Abnormality - Diabetes-Related

Hepatopulmonary Syndrome

Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis

Ovarian Clear Cell Carcinoma

Clear-Cell Ovarian Carcinoma

Pancreatic Ductal Carcinoma

Carcinoma, Pancreatic Ductal

Malignant Neoplasm Of Duct Of Wirsung

Pancreatic Duct Cancer

Carcinoma Pancreatic Ductal

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Acquired Hypogammaglobulinemia

Common Variable Immune Deficiency

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Bone Sarcoma

Cystadenocarcinoma

Diabetes Mellitus

Diabetes

Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow

Bone Marrow Neoplasm

Bone Marrow Tumor

Malignant Bone Marrow Tumor

Myeloproliferative Disorders

Bone Marrow Neoplasms

Myeloproliferative Disease

Chronic Myeloproliferative Disorder

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome

KTS

Ktw Syndrome

Angioosteohypertrophy Syndrome

Angio-Osteohypertrophy Syndrome

Klippel Trenaunay Syndrome

Klippel-Trénaunay-Weber Syndrome

Haemangiectatic Hypertrophy

Weber-Klippel-Trenaunay

Congenital Dysplastic Angiopathy

Klippel-Trenaunay Disease

Weber Klippel Trenaunay

Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Myocardial Stunning

Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Bone Inflammation Disease

Osteitis

Bone Inflammatory Disease

Inflammatory Disorder Of Bone

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Ovarian Disease

Ovarian Dysfunction

Ovarian Diseases

Ovarian Disorders

Disorder Of Endocrine Ovary

Diabetic Angiopathy

Diabetic Angiopathies

Diabetic Peripheral Angiopathy

Diabetic Vascular Disorder

Hypopharynx Cancer

Hypopharyngeal Cancer

Malignant Neoplasm Of Hypopharynx

Hypopharyngeal Neoplasms

Hypopharyngeal Carcinoma

Malignant Hypopharyngeal Tumor

Malignant Tumor Of Hypopharynx

Malignant Tumour Of Hypopharynx

Uterine Carcinosarcoma

Carcinosarcoma Of The Corpus Uteri

Mixed Mullerian Sarcoma Of Uterus

Malignant Mixed Müllerian Tumor Of The Corpus Uteri

Malignant Mixed Müllerian Tumor Of Corpus Uteri

Mixed Müllerian Cancer Of Corpus Uteri

Malignant Mixed Mullerian Tumor Of The Corpus Uteri

Mixed Mullerian Cancer Of Corpus Uteri

Uterine Corpus Carcinosarcoma

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni

Sbla Syndrome

LFS

Li-Fraumeni Familiar Cancer Susceptibility Syndrome

Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome

Lfs1

Li Fraumeni Syndrome

Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome

Lfl

Sbla Syndrome Li-Fraumeni-Like Syndrome

Li-Fraumeni Syndrome 1

Skull Base Meningioma

Meningioma Of The Skull Base

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy, Hypertrophic, Familial

Familial Hypertrophic Cardiomyopathy

Cardiomyopathy Hypertrophic Obstructive

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

Oropharynx Cancer

Oropharyngeal Cancer

Oropharyngeal Carcinoma

Malignant Neoplasm Of Oropharynx

Malignant Oropharyngeal Tumor

Malignant Tumor Of Oropharynx

Malignant Tumour Of Mesopharynx

Oropharyngeal Cancer, Adult

Cancer Of The Oropharynx

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Cowden Syndrome 1

Pten Hamartoma Tumor Syndrome

Bannayan-Riley-Ruvalcaba Syndrome

Lhermitte-Duclos Disease

Bannayan-Zonana Syndrome

Phts

Riley-Smith Syndrome

Bzs

Ruvalcaba-Myhre-Smith Syndrome

Multiple Hamartoma Syndrome

Rmss

Brrs

Dysplastic Gangliocytoma Of The Cerebellum

CWS1

Cs

Cd

Mham

Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

Macrocephaly Multiple Lipomas And Hemangiomata

Bannayan-Ruvalcaba-Riley Syndrome

Myhre-Riley-Smith Syndrome

LDD

Cerebelloparenchymal Disorder Vi

Hamartoma Syndrome, Multiple

Bbrs

Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

Macrocephaly, Multiple Lipomas, And Hemangiomata

Macrocephaly Pseudopapilledema And Multiple Hemangiomas

Ruvalcaba -Myhre-Smith Syndrome

Ruvalcaba-Myhre Syndrome

Cowden Disease

Macrocephaly Pseudopapilledema And Multiple Hemangiomata

Cerebellar Granule Cell Hypertrophy And Megalencephaly

Cpd6

Lhermitte-Duclos Syndrome

Pten Hamartoma Tumor Syndromes

Cowden Syndrome, Type 1

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Ovary Epithelial Cancer

Ovarian Surface Epithelial-Stromal Tumor

Epithelial Tumor Of Ovary

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Cardiovascular Disease

Sensory System Disease

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Retinal Ischemia

Hepatoblastoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

In Situ Carcinoma

Carcinoma In Situ

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

CMM1

Melanoma, Cutaneous Malignant

Cmm

Melanoma, Malignant

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Bile Duct Adenocarcinoma

Skin Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Skin

Epidermoid Skin Carcinoma

Squamous Cell Carcinoma Of The Skin

Squamous Cell Epithelioma Of Skin

Cutaneous Squamous Cell Carcinoma

Scc - [Squamous Cell Carcinoma] Of Skin

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Carbuncle

Carbuncle And Furuncle Of Any Part Of Face Except Eye

Carbuncle And Furuncle Of Buttock

Carbuncle And Furuncle Of Face

Carbuncle And Furuncle Of Foot

Carbuncle And Furuncle Of Gluteal Region

Carbuncle And Furuncle Of Hand

Carbuncle And Furuncle Of Leg Except Foot

Carbuncle And Furuncle Of Neck

Carbuncle And Furuncle Of Trunk

Carbuncle And Furuncle Of Upper Arm And Forearm

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Adrenal Carcinoma

Adrenal Cancer

Adrenal Gland Cancer

Malignant Neoplasm Of Adrenal Gland

Adrenal Gland Neoplasms

Carcinoma Of The Adrenal Gland

Adrenal Neoplasm

Malignant Adrenal Tumor

Neoplasm Of Adrenal Gland

Tumor Of The Adrenal Gland

Adrenal Gland Neoplasm

Adrenocortical Carcinoma

Adrenal Gland Malignancy

Suprarenal Cancer

Malignant Neoplasm Of Suprarenal Gland

Malignant Neoplasm Of Adrenal Gland, Unspecified

Malignant Tumour Of Adrenal Gland

Suprarenal Gland Cancer

Primary Malignant Neoplasm Of Adrenal Gland

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Myopathy

Muscular Diseases

Myopathies

Pulmonary Adenocarcinoma In Situ

Bronchioalveolar Carcinoma

Malignant Astrocytoma

Astrocytic Tumor

Astrocytoma Of Brain

Astrocytoma Of Cerebrum

Astroglioma

Cerebral Astrocytoma

Astrocytoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease

Pleural Cancer

Pleural Neoplasms

Neoplasm Of Pleura

Pleural Tumor

Malignant Tumor Of Pleura

Pleural Cavity Cancer

Primary Malignant Neoplasm Of Parietal Pleura

Primary Malignant Neoplasm Of Pleura

Primary Malignant Neoplasm Of Visceral Pleura

Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Malignant Ovarian Surface Epithelial-Stromal Tumor

Thyroid Tumor

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Respiratory System Benign Neoplasm

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi

Cloves Syndrome

Clove Syndrome

Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities

Clove Syndrome, Somatic

Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome

CLOVE

Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities

Congenital Arteriovenous Malformation

Arteriovenous Hemangioma

Nevus

Melanocytic Nevus

Benign Melanocytic Nevus

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Degeneration

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2

Overnutrition

Lipid Storage Disease

Lipoidosis

Inborn Lipid Storage Disorder

Lipoid Storage Diseas

Lipid Storage Diseases

Lipidoses

Thymus Gland Disease

Disease Of Thymus Gland

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism

Disorder Of Carbohydrate Metabolism

Carbohydrate Metabolism, Inborn Errors

Disorder Of Carbohydrate Transport And Metabolism

Inborn Carbohydrate Metabolism Disorder

Inborn Carbohydrate Metabolic Disorder

Carbohydrate Metabolism Disorder

Carbohydrate Metabolism Disorders

Disorders Of Carbohydrate Metabolism

Congenital Disorders Of Carbohydrate Metabolism

Inherited Disorders Of Carbohydrate Metabolism

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome

Gorlin Syndrome

Nbccs

BCNS

Gorlin-Goltz Syndrome

Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies

Cerebral Gigantism Jaw Cysts

Cramer Niederdellmann Syndrome

Gorlin Syndrome Or Gorlin-Goltz Syndrome

Naevoid Basal Cell Carcinoma Syndrome

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Adenoid Cystic Carcinoma

Adenocystic Carcinoma

Cribriform Carcinoma

Cylindroma

Carcinoma Adenoid Cystic

Carcinoma, Adenoid Cystic

Adenoid Cystic Carcinoma Of Salivary Gland

Eccrine Dermal Cylindroma

Carcinoma, Cribriform

Gastrointestinal System Benign Neoplasm

Teratoma

Teratomas

Tonsil Cancer

Tonsillar Neoplasms

Malignant Neoplasm Of Faucial Tonsil

Malignant Neoplasm Of Palatine Tonsil

Malignant Neoplasm Of Tonsil, Faucial

Malignant Tonsillar Tumor

Malignant Tumor Of Tonsil

Tonsillar Carcinoma

Malignant Neoplasm Tonsil

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Plasmacytoma

Solitary Plasmacytoma

Solitary Myeloma

Myeloma - Solitary

Myeloma, Solitary

Plasmacytoma - Category

Solitary Osseous Plasmacytoma

Solitary Plasmacytoma Without Mention Of Remission

Localised Malignant Plasma Cell Tumour Nos

Plasmacytoma Nos

Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay

Aarskog-Ose-Pande Syndrome

Lipodystrophy, Partial, With Rieger Anomaly And Short Stature

Lipodystrophy-Rieger Anomaly-Diabetes Syndrome

Rieger Anomaly-Partial Lipodystrophy Syndrome

Partial Lipodystrophy With Rieger Anomaly And Short Stature

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay

Growth Retardation-Rieger Anomaly

Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay

SHORTS

Spinal Cord Disease

Spinal Cord Diseases

Myelopathy

Bone Marrow Diseases

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma

Endometrial Adenoacanthoma

Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

Adenocarcinoma Of Endometrium

Adenocarcinoma Of The Endometrium

Adenocarcinoma Of Uterus

Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

Endometrioid Adenoma Or Carcinoma

Endometrioid Adenomas And Carcinomas

Endometrioid Carcinoma Of Endometrium

Endometrium Adenocarcinoma

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Plexiform Neurofibroma

Neurofibroma Plexiform

Neurofibroma, Plexiform

Primary Cutaneous Amyloidosis

Plca

Primary Localized Cutaneous Amyloidosis

Familial Primary Localized Cutaneous Amyloidosis

Amyloidosis Ix

Lichen Amyloidosis Familial

Amyloidosis, Primary Cutaneous

Pca

Amyloidosis 9

Amyloidosis Familial Cutaneous Lichen

Fplca

Familial Lichen Amyloidosis

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular

Nevus, Epidermal

Epidermal Nevus

Woolly Hair Nevus

Epidermal Naevus

Epidermal Nevus Syndrome

Nevus, Keratinocytic, Nonepidermolytic

Epidermal Nevus, Somatic

Nevus, Epidermal, Somatic

Nevus Sebaceous Or Woolly Hair Nevus, Somatic

Nonepidermolytic Keratinocytic Nevus

Epidermal Hamartoma Syndrome

Wooly Hair Nevus

Keratinocytic Non-Epidermolytic Nevus

KNEN

Pigmented Moles

Organoid Nevus Phakomatosis

Nevus Sebaceous

Melanocytic Nevus

Melanocytic Nevus Of Skin

Muscular Disease

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Subependymal Glioma

Mixed Subependymoma-Ependymoma

Subependymal Astrocytoma

Who Grade I Ependymal Tumor

Glioma, Subependymal

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma

Anus Cancer

Anal Cancer

Malignant Anal Tumor

Cancer Of The Anus

Malignant Neoplasm Of Anus

Anal Carcinoma

Anus Neoplasms

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Vascular Anomaly

Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a

Multiple Pterygium Syndrome, Autosomal Dominant

CPSFS1A

Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a

Autosomal Dominant Disease

Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a

Cpskf1a

Pterygium Syndrome, Multiple

Autosomal Dominant

Arthrogryposis, Distal, Type 8, Formerly

Da8, Formerly

Autosomal Dominant Multiple Pterygium Syndrome

Distal Arthrogryposis Type 8

Arthrogryposis, Distal, Type 8

Da8

Pterygium Syndrome, Multiple, Autosomal Dominant

Autosomal Dominant Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Endocervical Carcinoma

Carcinoma Of Endocervix

Carcinoma Of The Endocervix

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Skin Carcinoma

Skin Cancer

Carcinoma Of Skin

Ca - Skin Cancer

Cancer Of Skin

Malignant Neoplasm Of Skin

Melanoma And Non-Melanoma Skin Cancer

Skin Cancers

Cancer, Skin

Low Grade Glioma

Benign Glioma

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Ischemia

Acute Coronary Syndrome

Limb Ischemia

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Bile Duct Cancer

Bile Duct Carcinoma

Extrahepatic Bile Duct Carcinoma

Carcinoma Of Extrahepatic Bile Duct

Extrahepatic Bile Duct Cancer

Bile Duct Neoplasms

Bile Duct Tumor

Ca Extrahepatic Bile Ducts

Malignant Neoplasm Of The Extrahepatic Bile Duct

Bile Duct Extrahepatic Carcinoma

Malignant Tumor Of Extrahepatic Bile Duct

Lymphangioma

Lymphatic Malformation

Lymphatic Malformations

Benign Lymphangioma

Congenital Lymphangioma

Lymphangiomas

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Localized Osteosarcoma

Localised Osteogenic Sarcoma

Localised Osteosarcoma

Localized Osteogenic Sarcoma

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma

Intrahepatic Bile Duct Carcinoma

Peripheral Cholangiocarcinoma

Peripheral Intrahepatic Cholangiocarcinoma

Adenocarcinoma Of Intra-Hepatic Bile Ducts

Cholangiocarcinoma, Unspecified Site

Cholangiocarcinoma Of Liver

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Hyperostosis

Hypertrophy Of Bone

Bone Hypertrophy

Bone Thickening

Periosteum Thickening

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Intestinal Benign Neoplasm

Intestinal Neoplasms

Intestinal Tumors

Intestine Growth

Neoplasm Of Intestinal Tract

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Estrogen-Receptor Negative Breast Cancer

Bile Duct Disease

Bile Duct Diseases

Bile Duct Disorder

Disorder Of Bile Duct

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site

Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Rhabdomyosarcoma

Neutropenia

Leukopenia

Benign Ependymoma

Ependymoma

Epithelial Ependymoma

Who Grade Ii Ependymal Tumor

Myxopapillary Ependymoma

Proteus Syndrome

Proteus Syndrome, Somatic

Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome

Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly

Wiedemann'S Syndrome

Hemihypertrophy And Macrocephaly

Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly

Ps

PROTEUSS

Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly

Integumentary System Disease

Infratentorial Cancer

Infratentorial Neoplasms

Brain Neoplasm, Infratentorial

Malignant Infratentorial Tumors

Hemangioma

Hemangiomas

Pancreatic Adenocarcinoma

Adenocarcinoma Of Pancreas

Adenocarcinoma Of The Pancreas

Pancreas Adenocarcinoma

Malignant Exocrine Neoplasm

Primary Pancreatic Adenocarcinoma

Adenocarcinoma Of Islet Cell Of Pancreas

Islet Cell Adenocarcinoma Of Unspecified Site

Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Ovary Adenocarcinoma

Ovarian Adenocarcinoma

Adenocarcinoma Of The Ovary

Ovarian Adenoacanthoma

Adenocarcinoma Of Ovary

High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas

Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Ovarian Serous Cystadenocarcinoma

Serous Cystadenoma

Cystadenoma Serous

Cystadenoma, Serous

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Cerebral Artery Occlusion

Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Breast Carcinoma In Situ

Carcinoma In Situ Of Breast

Non-Infiltrating Carcinoma Of Breast

Breast Cancer In Situ

Colitis

Autosomal Genetic Disease

Autosomal Hereditary Disorder

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 5

MVCD5

Retinopathy, Diabetic

Diabetic Nephropathy

Retinopathy, Diabetic, Susceptibility To

Retinal Abnormality - Diabetes-Related

Hepatopulmonary Syndrome

Diabetes Mellitus

Diabetes

Myocardial Stunning

Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Bone Inflammation Disease

Osteitis

Bone Inflammatory Disease

Inflammatory Disorder Of Bone

Hypopharynx Cancer

Hypopharyngeal Cancer

Malignant Neoplasm Of Hypopharynx

Hypopharyngeal Neoplasms

Hypopharyngeal Carcinoma

Malignant Hypopharyngeal Tumor

Malignant Tumor Of Hypopharynx

Malignant Tumour Of Hypopharynx

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Ovary Epithelial Cancer

Ovarian Surface Epithelial-Stromal Tumor

Epithelial Tumor Of Ovary

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Hepatoblastoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Lipid Storage Disease

Lipoidosis

Inborn Lipid Storage Disorder

Lipoid Storage Diseas

Lipid Storage Diseases

Lipidoses

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome

Gorlin Syndrome

Nbccs

BCNS

Gorlin-Goltz Syndrome

Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies

Cerebral Gigantism Jaw Cysts

Cramer Niederdellmann Syndrome

Gorlin Syndrome Or Gorlin-Goltz Syndrome

Naevoid Basal Cell Carcinoma Syndrome

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2

Gastrointestinal System Benign Neoplasm

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Spinal Cord Disease

Spinal Cord Diseases

Myelopathy

Bone Marrow Diseases

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Plexiform Neurofibroma

Neurofibroma Plexiform

Neurofibroma, Plexiform

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular

Nevus, Epidermal

Epidermal Nevus

Woolly Hair Nevus

Epidermal Naevus

Epidermal Nevus Syndrome

Nevus, Keratinocytic, Nonepidermolytic

Epidermal Nevus, Somatic

Nevus, Epidermal, Somatic

Nevus Sebaceous Or Woolly Hair Nevus, Somatic

Nonepidermolytic Keratinocytic Nevus

Epidermal Hamartoma Syndrome

Wooly Hair Nevus

Keratinocytic Non-Epidermolytic Nevus

KNEN

Pigmented Moles

Organoid Nevus Phakomatosis

Nevus Sebaceous

Melanocytic Nevus

Melanocytic Nevus Of Skin

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Low Grade Glioma

Benign Glioma

Bile Duct Cancer

Bile Duct Carcinoma

Extrahepatic Bile Duct Carcinoma

Carcinoma Of Extrahepatic Bile Duct

Extrahepatic Bile Duct Cancer

Bile Duct Neoplasms

Bile Duct Tumor

Ca Extrahepatic Bile Ducts

Malignant Neoplasm Of The Extrahepatic Bile Duct

Bile Duct Extrahepatic Carcinoma

Malignant Tumor Of Extrahepatic Bile Duct

Diabetic Encephalopathy

Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma

Toxic Encephalopathy

Neurotoxicity

Neurotoxicity Syndromes

Neurotoxicity Syndrome

Encephalopathy, Toxic

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma

Adrenal Cortex Carcinoma

Carcinoma Of The Adrenal Cortex

Acc

Adrenocortical Cancer

Carcinoma Adrenocortical

Tumor Of Meninges

Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Cowden Syndrome 6

CWS6

Cowden Syndrome, Type 6

Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Female Reproductive Endometrioid Cancer

Endometrioid Tumor

Endometrioid Neoplasm

Female Reproductive Endometrioid Neoplasm

Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre

Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina

Cardiovascular Organ Benign Neoplasm

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Hyperglycemia

Thymoma

Primary Thymic Epithelial Neoplasm

Primary Thymic Epithelial Tumor

Thymus Neoplasms

Retinal Vascular Disease

Retinal Vascular

Retina Circulation Disorder

Retinal Vascular Disorder

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Thymus Cancer

Thymic Tumor

Thymus Neoplasm

Thymus Neoplasms

Malignant Neoplasm Of Thymus

Neoplasm Of Thymus

Thymic Neoplasm

Thymic Neoplasms

Thymoma, Familial

Thymic Carcinoma

Thymoma, Type C

Cancer Of Thymus

Malignant Tumour Of Thymus

Primary Malignant Neoplasm Of Thymus

Thymic Glandular Cancer

Thymus Gland Cancer

Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis

Reproductive Organ Benign Neoplasm

Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder

Pre-Malignant Neoplasm

Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Leptin

Teeth Hard Tissue Disease

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Ovarian Cystadenocarcinoma

Cystadenocarcinoma Of Ovary

Cystadenocarcinoma Of The Ovary

Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis

Ovarian Clear Cell Carcinoma

Clear-Cell Ovarian Carcinoma

Cystadenocarcinoma

Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome

KTS

Ktw Syndrome

Angioosteohypertrophy Syndrome

Angio-Osteohypertrophy Syndrome

Klippel Trenaunay Syndrome

Klippel-Trénaunay-Weber Syndrome

Haemangiectatic Hypertrophy

Weber-Klippel-Trenaunay

Congenital Dysplastic Angiopathy

Klippel-Trenaunay Disease

Weber Klippel Trenaunay

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Skull Base Meningioma

Meningioma Of The Skull Base

Oropharynx Cancer

Oropharyngeal Cancer

Oropharyngeal Carcinoma

Malignant Neoplasm Of Oropharynx

Malignant Oropharyngeal Tumor

Malignant Tumor Of Oropharynx

Malignant Tumour Of Mesopharynx

Oropharyngeal Cancer, Adult

Cancer Of The Oropharynx

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

CMM1

Melanoma, Cutaneous Malignant

Cmm

Melanoma, Malignant

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Bile Duct Adenocarcinoma

Carbuncle

Carbuncle And Furuncle Of Any Part Of Face Except Eye

Carbuncle And Furuncle Of Buttock

Carbuncle And Furuncle Of Face

Carbuncle And Furuncle Of Foot

Carbuncle And Furuncle Of Gluteal Region

Carbuncle And Furuncle Of Hand

Carbuncle And Furuncle Of Leg Except Foot

Carbuncle And Furuncle Of Neck

Carbuncle And Furuncle Of Trunk

Carbuncle And Furuncle Of Upper Arm And Forearm

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism

Disorder Of Carbohydrate Metabolism

Carbohydrate Metabolism, Inborn Errors

Disorder Of Carbohydrate Transport And Metabolism

Inborn Carbohydrate Metabolism Disorder

Inborn Carbohydrate Metabolic Disorder

Carbohydrate Metabolism Disorder

Carbohydrate Metabolism Disorders

Disorders Of Carbohydrate Metabolism

Congenital Disorders Of Carbohydrate Metabolism

Inherited Disorders Of Carbohydrate Metabolism

Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple

Adenoid Cystic Carcinoma

Adenocystic Carcinoma

Cribriform Carcinoma

Cylindroma

Carcinoma Adenoid Cystic

Carcinoma, Adenoid Cystic

Adenoid Cystic Carcinoma Of Salivary Gland

Eccrine Dermal Cylindroma

Carcinoma, Cribriform

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Endocervical Carcinoma

Carcinoma Of Endocervix

Carcinoma Of The Endocervix

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Lymphangioma

Lymphatic Malformation

Lymphatic Malformations

Benign Lymphangioma

Congenital Lymphangioma

Lymphangiomas

Insulin-Like Growth Factor I

Insulin-Like Growth Factor I Deficiency

IGF1 DEFICIENCY

Insulin-Like Growth Factor I, Resistance To

Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor I Resistance

IGF1RES

Igf-I Resistance

Growth Retardation With Sensorineural Deafness And Mental Retardation

Somatomedin, End-Organ Insensitivity To

Somatomedin-C

Somatomedin-C, Resistance To

Insulin-Like Growth Factor 1 Resistance To

Igf-1 Resistance

Somatomedin End-Organ Insensitivity To

Somatomedin-C Resistance To

Growth Delay-Deafness-Intellectual Disability Syndrome

Growth Delay-Hearing Loss-Intellectual Disability Syndrome

Igf-1 Deficiency

Primary Insulin-Like Growth Factor Deficiency

Resistance To Igf-1

Insulin-Like Growth Factor 1 Resistance

End-Organ Insensitivity To Somatomedin

Igf1 Resistance

Resistance To Insulin-Like Growth Factor I

Resistance To Somatomedin-C

Insulin-Like Growth Factor 1, Resistance To

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Squamous Cell Skin Cancer

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Brain Cancer

Malignant Neoplasm Of Brain

Adult Brain Tumor

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Ocular Hypertension

Hypertension, Ocular

Intraocular Pressure Increase

Oh - [Ocular Hypertension]

Oht - [Ocular Hypertension]

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Serous Cystadenocarcinoma

Serous Adenocarcinoma

Cystadenocarcinoma, Serous

Serous Carcinoma

Cystadenocarcinoma Serous

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity

Retrolental Fibroplasia

EVR1

Criswick-Schepens Syndrome

Rop

Exudative Vitreoretinopathy, Familial, Autosomal Dominant

Fevr, Autosomal Dominant

Premature Retinopathy

Vitreoretinopathy, Exudative 1

Autosomal Dominant Familial Exudative Vitreoretinopathy

Fevr

Vitreoretinopathy, Exudative, Type 1

Retinopathy Of Prematurity Nos

Rlf- [Retrolental Fibroplasia]

Rop - [Retinopathy Of Prematurity]

Terry Syndrome

Estrogen-Receptor Positive Breast Cancer

Anus Disease

Anal Fissure

Ulcer Of Anus

Anus Diseases

Anal Disease

Anal Fissure And Fistula

Anal Ulcer

Fissure In Ano

Nontraumatic Tear Of Anus

Solitary Anal Ulcer

Abnormality Of The Anus

Anal Disorders

Ulcer Of Anus And Rectum

Solitary Ulcer Of Anus

Stercoral Ulcer Of Anus

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung

Squamous Cell Lung Carcinoma

Epidermoid Cell Carcinoma Of The Lung

Squamous Cell Lung Cancer

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Breast Lobular Carcinoma

Cancer, Breast, Lobular

Lobular Breast Carcinoma

Autonomic Nervous System Neoplasm

Tumor Of Autonomic Nervous System

Aging

Muscle Cancer

Myosarcoma

Malignant Neoplasm Of Muscle

Malignant Tumor Of Muscle

Malignant Tumor Of The Muscle

Muscle Neoplasms

Myomatous Neoplasm

Inherited Metabolic Disorder

Inborn Errors Of Metabolism

Inborn Metabolism Disorder

Metabolic Hereditary Disorder

Inborn Error Of Metabolism

Inborn Metabolic Disorder

Metabolism, Inborn Errors

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Malignant Exocrine Pancreas Neoplasm

Malignant Neoplasm Of The Exocrine Pancreas

Malignant Tumor Of Exocrine Pancreas

Malignant Tumour Of Exocrine Pancreas

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Skin Papilloma

Cutaneous Papilloma

Papilloma Of Skin

Papilloma Skin

Brain Glioma

Lower Grade Glioma

Intracranial Glioma

Glioma Nos

Immunodeficiency 14

Activated Pi3k-Delta Syndrome

Apds

Pasli Disease

Imd14

Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation

P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency

Uterine Benign Neoplasm

Tongue Disease

Abnormality Of The Tongue

Tongue Diseases

Tongue Disorders

Disorder Of Tongue

Glossopathy

Unspecified Condition Of The Tongue

Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos

Cell Type Benign Neoplasm

Pfeiffer Syndrome

Infectious Mononucleosis

Acs5

Craniofacial-Skeletal-Dermatologic Dysplasia

Acs V

Noack Syndrome

Gammaherpesviral Mononucleosis

Acrocephalosyndactyly Type 5

Pfeiffer Syndrome Type 3

Acrocephalosyndactyly, Type V

Glandular Fever

Pfeiffer Type Acrocephalosyndactyly

Pfeiffer Syndrome Type 2

Acrocephalosyndactylia Type V

Filatov'S Disease

Monocytic Angina

Mononucleosis

Pfeiffer'S Disease

Acsv

Acrocephalosyndactyly, Type 5

Craniofacial-Skeletal-Dermatologic Syndrome

Pfeiffer Syndrome Type 1

Classic Pfeiffer Syndrome

PS

Pfeiffer Syndrome Variant

Dysplasia, Craniofacial-Skeletal-Dermatologic

Pfeiffer

Kissing Disease

Infectious Adenitis

Pfeiffer Disease

Childhood Osteosarcoma

Pediatric Osteosarcoma

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified

Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders

Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Congenital Megacolon

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

Hirschsprung'S Disease

Congenital Intestinal Aganglionosis

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Papilloma

Papillomatosis

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Acquired Hypogammaglobulinemia

Common Variable Immune Deficiency

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Bone Sarcoma

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow

Bone Marrow Neoplasm

Bone Marrow Tumor

Malignant Bone Marrow Tumor

Myeloproliferative Disorders

Bone Marrow Neoplasms

Myeloproliferative Disease

Chronic Myeloproliferative Disorder

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Diabetic Angiopathy

Diabetic Angiopathies

Diabetic Peripheral Angiopathy

Diabetic Vascular Disorder

Uterine Carcinosarcoma

Carcinosarcoma Of The Corpus Uteri

Mixed Mullerian Sarcoma Of Uterus

Malignant Mixed Müllerian Tumor Of The Corpus Uteri

Malignant Mixed Müllerian Tumor Of Corpus Uteri

Mixed Müllerian Cancer Of Corpus Uteri

Malignant Mixed Mullerian Tumor Of The Corpus Uteri

Mixed Mullerian Cancer Of Corpus Uteri

Uterine Corpus Carcinosarcoma

Cowden Syndrome 1

Pten Hamartoma Tumor Syndrome

Bannayan-Riley-Ruvalcaba Syndrome

Lhermitte-Duclos Disease

Bannayan-Zonana Syndrome

Phts

Riley-Smith Syndrome

Bzs

Ruvalcaba-Myhre-Smith Syndrome

Multiple Hamartoma Syndrome

Rmss

Brrs

Dysplastic Gangliocytoma Of The Cerebellum

CWS1

Cs

Cd

Mham

Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

Macrocephaly Multiple Lipomas And Hemangiomata

Bannayan-Ruvalcaba-Riley Syndrome

Myhre-Riley-Smith Syndrome

LDD

Cerebelloparenchymal Disorder Vi

Hamartoma Syndrome, Multiple

Bbrs

Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

Macrocephaly, Multiple Lipomas, And Hemangiomata

Macrocephaly Pseudopapilledema And Multiple Hemangiomas

Ruvalcaba -Myhre-Smith Syndrome

Ruvalcaba-Myhre Syndrome

Cowden Disease

Macrocephaly Pseudopapilledema And Multiple Hemangiomata

Cerebellar Granule Cell Hypertrophy And Megalencephaly

Cpd6

Lhermitte-Duclos Syndrome

Pten Hamartoma Tumor Syndromes

Cowden Syndrome, Type 1

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

In Situ Carcinoma

Carcinoma In Situ

Skin Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Skin

Epidermoid Skin Carcinoma

Squamous Cell Carcinoma Of The Skin

Squamous Cell Epithelioma Of Skin

Cutaneous Squamous Cell Carcinoma

Scc - [Squamous Cell Carcinoma] Of Skin

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Adrenal Carcinoma

Adrenal Cancer

Adrenal Gland Cancer

Malignant Neoplasm Of Adrenal Gland

Adrenal Gland Neoplasms

Carcinoma Of The Adrenal Gland

Adrenal Neoplasm

Malignant Adrenal Tumor

Neoplasm Of Adrenal Gland

Tumor Of The Adrenal Gland

Adrenal Gland Neoplasm

Adrenocortical Carcinoma

Adrenal Gland Malignancy

Suprarenal Cancer

Malignant Neoplasm Of Suprarenal Gland

Malignant Neoplasm Of Adrenal Gland, Unspecified

Malignant Tumour Of Adrenal Gland

Suprarenal Gland Cancer

Primary Malignant Neoplasm Of Adrenal Gland

Pulmonary Adenocarcinoma In Situ

Bronchioalveolar Carcinoma

Malignant Astrocytoma

Astrocytic Tumor

Astrocytoma Of Brain

Astrocytoma Of Cerebrum

Astroglioma

Cerebral Astrocytoma

Astrocytoma

Pleural Cancer

Pleural Neoplasms

Neoplasm Of Pleura

Pleural Tumor

Malignant Tumor Of Pleura

Pleural Cavity Cancer

Primary Malignant Neoplasm Of Parietal Pleura

Primary Malignant Neoplasm Of Pleura

Primary Malignant Neoplasm Of Visceral Pleura

Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Malignant Ovarian Surface Epithelial-Stromal Tumor

Thyroid Tumor

Respiratory System Benign Neoplasm

Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi

Cloves Syndrome

Clove Syndrome

Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities

Clove Syndrome, Somatic

Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome

CLOVE

Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities

Congenital Arteriovenous Malformation

Arteriovenous Hemangioma

Nevus

Melanocytic Nevus

Benign Melanocytic Nevus

Thymus Gland Disease

Disease Of Thymus Gland

Teratoma

Teratomas

Plasmacytoma

Solitary Plasmacytoma

Solitary Myeloma

Myeloma - Solitary

Myeloma, Solitary

Plasmacytoma - Category

Solitary Osseous Plasmacytoma

Solitary Plasmacytoma Without Mention Of Remission

Localised Malignant Plasma Cell Tumour Nos

Plasmacytoma Nos

Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay

Aarskog-Ose-Pande Syndrome

Lipodystrophy, Partial, With Rieger Anomaly And Short Stature

Lipodystrophy-Rieger Anomaly-Diabetes Syndrome

Rieger Anomaly-Partial Lipodystrophy Syndrome

Partial Lipodystrophy With Rieger Anomaly And Short Stature

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay

Growth Retardation-Rieger Anomaly

Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay

SHORTS

Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma

Endometrial Adenoacanthoma

Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

Adenocarcinoma Of Endometrium

Adenocarcinoma Of The Endometrium

Adenocarcinoma Of Uterus

Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

Endometrioid Adenoma Or Carcinoma

Endometrioid Adenomas And Carcinomas

Endometrioid Carcinoma Of Endometrium

Endometrium Adenocarcinoma

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Primary Cutaneous Amyloidosis

Plca

Primary Localized Cutaneous Amyloidosis

Familial Primary Localized Cutaneous Amyloidosis

Amyloidosis Ix

Lichen Amyloidosis Familial

Amyloidosis, Primary Cutaneous

Pca

Amyloidosis 9

Amyloidosis Familial Cutaneous Lichen

Fplca

Familial Lichen Amyloidosis

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Vascular Anomaly

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Limb Ischemia

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability

Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Gallbladder Disease

Gallbladder Diseases

Gall Bladder

Gall Bladder Diseases

Abnormal Gallbladder Function

Uveal Disease

Uveal Diseases

Tongue Carcinoma

Tongue Cancer

Malignant Neoplasm Of Tongue

Tongue Neoplasms

Tongue Neoplasm

Leukocyte Disease

Leukocyte Disorders

Hyperinsulinism

Hyperinsulinemia

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis

Nash

Nash - [Non-Alcoholic Steatohepatitis]

Non-Alcoholic Steatohepatosis

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Colon Adenoma

Adenomatous Polyp Of Colon

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Acquired Metabolic Disease

Brain Glioblastoma Multiforme

Brain Glioblastoma

Glioblastoma Multiforme Of Brain

Glioblastoma Nos

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Exanthem

Exanthema

Rash

Rashes

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Human Papillomavirus Infectious Disease

Hpv

Papillomavirus Infections

Human Papilloma Virus Infection

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Small Cell Cancer Of The Lung

Small Cell Lung Cancer

Small Cell Lung Carcinoma

Sclc

Small-Cell Cancer Of Lung

Lung Small Cell Carcinoma

Sclc1

Sccl

Cancer, Lung, Small Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell

Lung Carcinoma In Situ

Lung Oat Cell Carcinoma

Oat Cell Carcinoma

Carcinoma Oat Cell

Carcinoma, Small Cell

Subependymal Giant Cell Astrocytoma

Sega

Astrocytoma Subependymal Giant Cell

Subependymal Giant-Cell Astrocytoma

Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm

Neoplasm Of Mature B-Cells

Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Neurilemmoma

Schwannoma

Benign Schwannoma

Neurilemoma

Peripheral Fibroblastoma

Psammomatous Schwannoma

Neurolemmoma

Schwannomas

Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]

Peripheral Nervous System Neoplasm

Nerve Sheath Neoplasm

Peripheral Nervous System Neoplasms

Neoplasm Of Peripheral Nerve

Tumor Of Pns

Nerve Sheath Neoplasms

Nerve Sheath Tumors

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]

Chordoma

CHDM

Notochordoma

Notochordal Sarcoma

Chordoma, Susceptibility To

Chordocarcinoma

Chordoepithelioma

Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos

Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Acoustic Neurinoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]

Skin Melanoma

Cutaneous Melanoma

Malignant Ear Melanoma

Malignant Lip Melanoma

Malignant Lower Limb Melanoma

Malignant Melanoma Of Ear And/Or External Auricular Canal

Malignant Melanoma Of Skin Of Lower Limb

Malignant Melanoma Of Skin Of Trunk Except Scrotum

Malignant Melanoma Of Skin Of Upper Limb

Malignant Neck Melanoma

Malignant Scalp Melanoma

Malignant Trunk Melanoma

Malignant Upper Limb Melanoma

Melanoma, Cutaneous Malignant

Melanoma

Malignant Melanoma Of Skin

Melanoma Nos

Malignant Mole, Meaning Melanoma Of Unspecified Site

Melanoma Of Unspecified Site

Cutaneous Malignant Melanoma

Mm - [Malignant Melanoma]

Biliary Tract Disease

Biliary Tract Diseases

Biliary Tract Abnormality

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Pancreatic Ductal Carcinoma

Carcinoma, Pancreatic Ductal

Malignant Neoplasm Of Duct Of Wirsung

Pancreatic Duct Cancer

Carcinoma Pancreatic Ductal

Ovarian Disease

Ovarian Dysfunction

Ovarian Diseases

Ovarian Disorders

Disorder Of Endocrine Ovary

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni

Sbla Syndrome

LFS

Li-Fraumeni Familiar Cancer Susceptibility Syndrome

Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome

Lfs1

Li Fraumeni Syndrome

Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome

Lfl

Sbla Syndrome Li-Fraumeni-Like Syndrome

Li-Fraumeni Syndrome 1

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy, Hypertrophic, Familial

Familial Hypertrophic Cardiomyopathy

Cardiomyopathy Hypertrophic Obstructive

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Cardiovascular Disease

Sensory System Disease

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Retinal Ischemia

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Myopathy

Muscular Diseases

Myopathies

Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Degeneration

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2

Overnutrition

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Tonsil Cancer

Tonsillar Neoplasms

Malignant Neoplasm Of Faucial Tonsil

Malignant Neoplasm Of Palatine Tonsil

Malignant Neoplasm Of Tonsil, Faucial

Malignant Tonsillar Tumor

Malignant Tumor Of Tonsil

Tonsillar Carcinoma

Malignant Neoplasm Tonsil

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

Muscular Disease

Subependymal Glioma

Mixed Subependymoma-Ependymoma

Subependymal Astrocytoma

Who Grade I Ependymal Tumor

Glioma, Subependymal

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma

Anus Cancer

Anal Cancer

Malignant Anal Tumor

Cancer Of The Anus

Malignant Neoplasm Of Anus

Anal Carcinoma

Anus Neoplasms

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a

Multiple Pterygium Syndrome, Autosomal Dominant

CPSFS1A

Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a

Autosomal Dominant Disease

Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a

Cpskf1a

Pterygium Syndrome, Multiple

Autosomal Dominant

Arthrogryposis, Distal, Type 8, Formerly

Da8, Formerly

Autosomal Dominant Multiple Pterygium Syndrome

Distal Arthrogryposis Type 8

Arthrogryposis, Distal, Type 8

Da8

Pterygium Syndrome, Multiple, Autosomal Dominant

Autosomal Dominant Disorder

Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Skin Carcinoma

Skin Cancer

Carcinoma Of Skin

Ca - Skin Cancer

Cancer Of Skin

Malignant Neoplasm Of Skin

Melanoma And Non-Melanoma Skin Cancer

Skin Cancers

Cancer, Skin

Ischemia

Acute Coronary Syndrome

疾病名称

别名

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

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Clinical Phase

生物活性分子

(19)

目录号

产品名

作用方式

纯度

Phase

HY-15186

Ipatasertib

99.88%

Phase 4

HY-N0004

Oridonin

Inhibitor

99.89%

Phase 4

HY-15186A

Ipatasertib dihydrochloride

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99.27%

Phase 4

HY-15431

Capivasertib

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99.95%

Phase 3

HY-10358

MK-2206 dihydrochloride

99.99%

Phase 2

HY-19719

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99.32%

Phase 2

HY-15727

Afuresertib

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99.54%

Phase 2

HY-15965

Uprosertib

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99.74%

Phase 2

HY-19934A

Pifusertib hydrochloride

98.96%

Phase 2

HY-15727A

Afuresertib hydrochloride

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99.03%

Phase 2

HY-19719A

Miransertib hydrochloride

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99.74%

Phase 2

HY-19934

Pifusertib

/

Phase 2

HY-108232

MK-2206

/

Phase 2

HY-15965A

Uprosertib hydrochloride

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/

Phase 2

HY-10249

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Phase 1

HY-100018

BAY1125976

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99.74%

Phase 1

HY-16071

AT13148

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99.21%

Phase 1

HY-100501

M2698

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Phase 1

HY-137458

Vevorisertib

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/

Phase 1

Pre-clinical Phase

生物活性分子

(53)

Cat. No.

产品名

作用方式

纯度

是否罕见病

HY-18749

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≥98.0%

否

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98.97%

否

HY-107738

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否

HY-10425

A-443654

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否

HY-13254

A-674563

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99.87%

否

HY-N1435

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99.71%

否

HY-11005

BX-912

99.13%

否

HY-137458A

Vevorisertib trihydrochloride

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HY-12059

AT7867

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99.88%

否

HY-133120

INY-03-041

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A-674563 hydrochloride

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HY-16666

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HY-12059A

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HY-151504

ALM301

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99.33%

否

HY-145282

MS170

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99.72%

否

HY-19982

AKT-IN-6

Inhibitor

99.51%

否

HY-151613A

MS15 TFA

Degrader

99.86%

否

HY-50862

Akt1/Akt2-IN-1

Inhibitor

99.59%

否

HY-119016A

SK1-​I hydrochloride

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99.49%

否

HY-126257

AKT-IN-3

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99.29%

否

HY-134903

(32-Carbonyl)-RMC-5552

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HY-151613

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/

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HY-119016

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98.47%

否

HY-133120A

INY-03-041 trihydrochloride

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99.27%

否

HY-123390

DB07107

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/

否

HY-146459

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HY-148868

Akt1&PKA-IN-1

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HY-148868A

Akt1&PKA-IN-2

Inhibitor

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HY-160093

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98.82%

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HY-N8122

24-Methylenecycloartanyl ferulate

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98.05%

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HY-130985

9-Decyn-1-ol

/

否

HY-10357

MK-2206 free base

/

否

HY-132302

Hu7691

Inhibitor

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HY-132302A

Hu7691 free base

Inhibitor

/

否

HY-145281

MS98

Inhibitor

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HY-147935

NTQ1062

Inhibitor

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HY-107586

Demethylasterriquinone B1

Activator

/

否

HY-129119

Akt1/Akt2-IN-2

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否

HY-138767

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Inhibitor

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否

HY-143611

AKT-IN-8

Inhibitor

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否

HY-145244

APN/AKT-IN-1

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否

HY-147937

AKT-IN-13

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否

HY-153640

AKT-IN-14

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否

HY-153640A

AKT-IN-14 free base

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HY-154960

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HY-162285

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HY-W013816

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HY-W750451

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Azurin p28 peptide

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否

HY-112148

AKT-IN-2

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/

否

直系同源

种属

基因名

来源

基因 ID

Felis catus

AKT1

VGNC

VGNC:59727

Macaca mulatta

AKT1

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VGNC:69776

Canis familiaris

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Mus musculus

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Rattus norvegicus

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实体化合物库

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虚拟筛选

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G

H

J

L

N

Q

S

T

X

Y

Z

确认